5 documents found, page 1 of 1
Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory ...
Fernandes, Mara Yone D.; Dobrachinski, Fernando; Silva, Henrique B.; Lopes, João Pedro; Gonçalves, Francisco Q.; Soares, Felix A AThe increased healthspan afforded by coffee intake provides novel opportunities to identify new therapeutic strategies. Caffeine has been proposed to afford benefits through adenosine A2A receptors, which can control synaptic dysfunction underlying some brain disease. However, decaffeinated coffee and other main components of coffee such as chlorogenic acids, also attenuate brain dysfunction, although it is unk...
Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 rec...
Simões, Ana P.; Silva, Carla G.; Marques, Joana M.; Pochmann, Daniela; Porciúncula, Lisiane O.; Ferreira, Sofia; Oses, Jean P.; Beleza, Rui de O.Despite the characteristic etiologies and phenotypes, different brain disorders rely on common pathogenic events. Glutamate-induced neurotoxicity is a pathogenic event shared by different brain disorders. Another event occurring in different brain pathological conditions is the increase of the extracellular ATP levels, which is now recognized as a danger and harmful signal in the brain, as heralded by the abili...
Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Tr...
Canas, Paula M.; Porciúncula, Lisiane O.; Simões, Ana Patrícia; Augusto, Elisabete de Oliveira; Silva, Henrique B.; Machado, Nuno J.; Gonçalves, NélioNeurodegeneration is a process transversal to neuropsychiatric diseases and the understanding of its mechanisms should allow devising strategies to prevent this irreversible step in brain diseases. Neurodegeneration caused by seizures is a critical step in the aggravation of temporal lobe epilepsy, but its mechanisms remain undetermined. Convulsions trigger an elevation of extracellular adenosine and upregulate...
Blockade of adenosine A2A receptors prevents staurosporine-induced apoptosis of...
Silva, Carla G.; Porciúncula, Lisiane O.; Canas, Paula M.; Oliveira, Catarina R.; Cunha, Rodrigo A.Since adenosine A2A receptor (A2ARs) blockade protects against noxious brain insults involving apoptosis, we directly tested if A2AR blockade prevents apoptosis induced by staurosporine (STS). Exposure of rat hippocampal neurons to STS (30 nM, 24 h) decreased neuronal viability while increasing the number apoptotic-like neurons and de-localizing mitochondria and cytochrome c immunoreactivities. This was prevent...
Long-term Effect of Convulsive Behavior on the Density of Adenosine A1 and A2A ...
Rebola, Nelson; Porciúncula, Lisiane O.; Lopes, Luísa V.; Oliveira, Catarina R.; Soares-da-Silva, Patrício; Cunha, Rodrigo A.Purpose: Adenosine is a neuromodulator that has been proposed to act as an anticonvulsant mainly via inhibitory A1 receptors, but recent data show that genetic deletion of facilitatory A2A receptors might also attenuate convulsions. Since both A1 and A2A receptors are prone to down- and upregulation in different stressful situations, we investigated if convulsive behavior leads to a long-term change in A1 and A...