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Foxp3 silencing with antisense oligonucleotide improves immunogenicity of an ad...
Batista-Duharte, Alexander [UNESP]; Sendra, Luis; Herrero, Maria José; Portuondo, Deivys Leandro [UNESP]; Téllez-Martínez, Damiana [UNESP]Made available in DSpace on 2021-06-25T10:56:14Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-04-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Background: In recent years, there has been great interest in developing molecular adjuvants based on antisense oligonucleotides (ASOs) targeting immunosuppressor pathways with inhibitory effects on regulatory T cells (Tregs) to improve immu...
Transient Foxp3(+) regulatory T-cell depletion enhances protective Th1/Th17 imm...
Batista-Duharte, Alexander [UNESP]; Téllez-Martínez, Damiana [UNESP]; de Andrade, Cleverton Roberto [UNESP]; Polesi, Marisa Campos [UNESP]Made available in DSpace on 2020-12-12T02:20:12Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-09-01; The role of regulatory T cells (Tregs) on protective immunity in fungal infections, is controversial. Sporotrichosis is an emerging and worldwide-distributed subcutaneous mycosis caused by various related thermodimorphic fungi of the genus Sporothrix. Previously, we showed an elevated percent of Tregs a...
Immunization with recombinant enolase of Sporothrix spp. (rSsEno) confers effec...
Portuondo, Deivys Leandro [UNESP]; Dores-Silva, Paulo Roberto; Ferreira, Lucas Souza [UNESP]; de Oliveira, Carlos S.; Téllez-Martínez, Damiana [UNESP]Made available in DSpace on 2020-12-12T01:46:48Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-12-01; In recent years, research has focused on the immunoreactive components of the Sporothrix schenckii cell wall that can be relevant targets for preventive and therapeutic vaccines against sporotrichosis, an emergent worldwide mycosis. In a previous study, we identified a 47-kDa enolase as an immunodominan...
Prophylactic and therapeutic vaccines against sporotrichosis. Feasibility and p...
Téllez-Martínez, Damiana [UNESP]; Batista-Duharte, Alexander [UNESP]; Portuondo, Deivys Leandro [UNESP]; Carlos, Iracilda Zeppone [UNESP]Made available in DSpace on 2019-10-06T16:37:01Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-01-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Sporotrichosis is an emergent subcutaneous mycosis of humans and some animals caused by dimorphic fungi of the genus Sporothrix. The disease occurs worldwide but is endemic or hyperendemic in tropical and subtropical areas. The epidemiology ...
Sporothrix schenckii cell wall proteins-stimulated bmdcs are able to induce a t...
Quinello, Camila [UNESP]; Ferreira, Lucas Souza [UNESP]; Picolli, Isabella [UNESP]; Loesch, Maria Luiza [UNESP]; Portuondo, Deivys Leandro [UNESP]Made available in DSpace on 2019-10-06T16:06:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-09-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Sporotrichosis is a subcutaneous mycosis affecting humans and other animals. The disease can be acquired by accidental inoculation of the fungus through the skin or through the respiratory system. Sporotrichosis can also be transmitted throu...
A recombinant enolase-montanide™ petgel a vaccine promotes a protective th1 imm...
Téllez-Martínez, Damiana [UNESP]; Portuondo, Deivys Leandro [UNESP]; Loesch, Maria Luiza [UNESP]; Batista-Duharte, Alexander [UNESP]Made available in DSpace on 2019-10-06T16:27:21Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-03-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); The effect of vaccination in fungal strains that suffered changes in their virulence by exposure to environmental contaminants is largely known. Growing reports of resistance to antifungal drugs and the emergence of new highly virulent strai...
Experimental sporotrichosis in a cyclophosphamide-induced immunosuppressed mice...
Manente, Francine Alessandra [UNESP]; Quinello, Camila [UNESP]; Ferreira, Lucas Souza [UNESP]; Andrade, Cleverton Roberto de [UNESP]Made available in DSpace on 2018-11-30T03:29:14Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-08-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); This report describes a model of host resistance for Sporothrix schenckii, an opportunistic fungi in immunosuppressed mice with cyclophosphamide (CY) to be used in studies of immunotoxicology and immunopharmacology. Two doses of CY were admi...
Sporothrix brasiliensis induces a more severe disease associated with sustained...
Batista-Duharte, Alexander [UNESP]; Téllez-Martínez, Damiana [UNESP]; Roberto de Andrade, Cleverton [UNESP]; Portuondo, Deivys Leandro [UNESP]Made available in DSpace on 2018-12-11T17:22:49Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-01-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Little is known about the differences in the CD4+ T-cell response induced by Sporothrix schenckii and Sporothrix brasiliensis, the most virulent species that cause sporotrichosis. Here, the helper (Th) and regulatory T cells (Tregs) response...
Comparative efficacy and toxicity of two vaccine candidates against Sporothrix ...
Portuondo, Deivys Leandro [UNESP]; Batista-Duharte, Alexander [UNESP]; Ferreira, Lucas Souza [UNESP]; de Andrade, Cleverton Roberto [UNESP]Made available in DSpace on 2018-12-11T17:13:05Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-08-03; Sporotrichosis is an important zoonosis in Brazil and the most frequent subcutaneous mycosis in Latin America, caused by different Sporothrix species. Currently, there is no effective vaccine available to prevent this disease. In this study, the efficacy and toxicity of the adjuvant Montanide™ Pet Gel A...
A cell wall protein-based vaccine candidate induce protective immune response a...
Portuondo, Deivys Leandro [UNESP]; Batista-Duharte, Alexander; Ferreira, Lucas Souza [UNESP]; Martínez, Damiana Téllez [UNESP]Made available in DSpace on 2018-12-11T17:06:13Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-02-01; Sporotrichosis is a subcutaneous mycosis caused by several closely related thermo-dimorphic fungi of the Sporothrix schenckii species complex, affecting humans and other mammals. In the last few years, new strategies have been proposed for controlling sporotrichosis owning to concerns about its growing ...