6 documents found, page 1 of 1
Multiomics Substrates of Resistance to Emerging Pathogens? Transcriptome and Pr...
Pinto, Luís; Torres, Carmen; Gil, Concha; Santos, Hugo M.; Capelo, José Luís; Borges, Vítor; Gomes, João Paulo; Silva, Catarina; Vieira, LuísAntibiotic resistance and hospital acquired infections are on the rise worldwide. Vancomycin-resistant enterococci have been reported in clinical settings in recent decades. In this multiomics study, we provide comprehensive proteomic and transcriptomic analyses of a vancomycin-resistant Enterococcus faecalis clinical isolate from a patient with a urinary tract infection. The previous genotypic profile of the s...
Multiomicssubstrates of resistance to emerging pathogens? transcriptome and pro...
Pinto, Luís; Torres, Carmen; Gil, Concha; Santos, Hugo M.; Capelo, José Luís; Borges, Vítor; Gomes, João Paulo; Silva, Catarina; Vieira, LuísAntibiotic resistance and hospital acquired infections are on the rise worldwide. Vancomycin-resistant enterococci have been reported in clinical settings in recent decades. In this multiomics study, we provide comprehensive proteomic and transcriptomic analyses of a vancomycin-resistant Enterococcus faecalis clinical isolate from a patient with a urinary tract infection. The previous genotypic profile of the s...
Multiomics Assessment of Gene Expression in a Clinical Strain of CTX-M-15-Produ...
Pinto, Luís; Torres, Carmen; Gil, Concha; Nunes-Miranda, Júlio D.; Santos, Hugo M.; Borges, Vítor; Gomes, João P.; Silva, Catarina; Vieira, LuísExtended-spectrum beta-lactamase (ESBL)-producing Escherichia coli strain C999 was isolated of a Spanish patient with urinary tract infection. Previous genotyping indicated that this strain presented a multidrug-resistance phenotype and carried beta-lactamase genes encoding CTX-M-15, TEM-1, and OXA-1 enzymes. The whole-cell proteome, and the membrane, cytoplasmic, periplasmic and extracellular sub-proteomes of ...
Quantitative differential proteomics of yeast extracellular matrix: there is mo...
Oliveira, Fábio Luís Silva Faria; Carvalho, Joana; Ferreira, Célia; Hernáez, Maria Luisa; Gil, Concha; Lucas, CândidaBackground: Saccharomyces cerevisiae multicellular communities are sustained by a scaffolding extracellular matrix, which provides spatial organization, and nutrient and water availability, and ensures group survival. According to this tissue-like biology, the yeast extracellular matrix (yECM) is analogous to the higher Eukaryotes counterpart for its polysaccharide and proteinaceous nature. Few works focused on...
Methodologies to generate, extract, purify and fractionate yeast ECM for analyt...
Faria-Oliveira, Fábio; Carvalho, Joana; Belmiro, Celso L R; Martinez-Gomariz, Montserrat; Hernaez, Maria Luisa; Pavão, Mauro; Gil, ConchaIn a multicellular organism, the extracellular matrix (ECM) provides a cell-supporting scaffold and helps maintaining the biophysical integrity of tissues and organs. At the same time it plays crucial roles in cellular communication and signalling, with implications in spatial organisation, motility and differentiation. Similarly, the presence of an ECM-like extracellular polymeric substance is known to support...
The transition of the European Proteomics Association into the future
Corthals, Gerry L.; Dunn, Mike; James, Peter; Gil, Concha; Penque, Deborah; Albar, Juan Pablo; Andrén, Per; Rabilloud, Thierry; Marko-Varga, GyorgyThe following report provides an overview of the discussions and outcome of the EuPA General Council meeting that took place in Estoril 20–21 October 2010. During the annual meeting future policy and action plans in a variety of areas are decided. Several important points were decided upon during this meeting including the expansion of the EuPA Executive Committee by introducing a new EuPA committee – EuPA Deve...