2 documents found, page 1 of 1
Enzyme kinetics, structural analysis and molecular modeling studies on a series...
Postigo,Matheus P; Krogh,Renata; Terni,Marcela F; Pereira,Humberto M; Oliva,Glaucius; Castilho,Marcelo S; Andricopulo,Adriano DThe enzyme purine nucleoside phosphorylase from Schistosoma mansoni (SmPNP) is an attractive molecular target for the development of novel drugs against schistosomiasis, a neglected tropical disease that affects about 200 million people worldwide. In the present work, enzyme kinetic studies were carried out in order to determine the potency and mechanism of inhibition of a series of SmPNP inhibitors. In additio...
Descriptor-and fragment-based QSAR models for a series of Schistosoma mansoni p...
Freitas,Humberto F; Postigo,Matheus P; Andricopulo,Adriano D; Castilho,Marcelo SThe enzyme purine nucleoside phosphorylase from Schistosoma mansoni (SmPNP) is an attractive molecular target for the treatment of major parasitic infectious diseases, with special emphasis on its role in the discovery of new drugs against schistosomiasis, a tropical disease that affects millions of people worldwide. In the present work, we have determined the inhibitory potency and developed descriptor- and fr...