5 documents found, page 1 of 1
Immunomodulatory inhibition of osteoclastogenesis by a marine microalgal ethano...
Carletti, Alessio; Pes, Katia; Tarasco, Marco; Rosa, Joana; Poudel, Sunil; Pereira, Hugo; Louro, Bruno; Cancela, M. Leonor; Laizé, VincentBackground: Targeting immune pathways to prevent bone loss represents a promising, yet underexplored therapeutic strategy. Methods: An ethanol-soluble fraction derived from the freeze-dried biomass of the marine microalga Skeletonema costatum (SKLT) was tested for its ability to modulate immune responses and inhibit osteoclastogenesis. Its effects were evaluated in a zebrafish model of bone regeneration, a meda...
Effect of antioxidant and Pro-oxidant on bone mineralization and remodelling
Poudel, SunilOsteoporosis is characterized by abnormal bone with low bone mass and degradation of skeleton microarchitecture, thus leading to bone fragility and risk of fracture. Oxidative stress induces an imbalance in osteoblast and osteoclast activity that leads to bone degradation, consequently resulting in osteoporotic phenotype. In addition, oxidative stress is a primary cause of secondary osteoporosis caused by speci...
Reversal of doxorubicin-Induced bone loss and mineralization by supplementation...
Poudel, Sunil; Izquierdo, Marisol; Cancela, M. Leonor; Gavaia, PauloDoxorubicin is a widely used chemotherapeutic drug known to induce bone loss. The mechanism behind doxorubicin-mediated bone loss is unclear, but oxidative stress has been suggested as a potential cause. Antioxidants that can counteract the toxic effect of doxorubicin on the bone would be helpful for the prevention of secondary osteoporosis. We used resveratrol, a natural antioxidant, and MitoTEMPO, a mitochond...
Resveratrol-mediated Reversal of Doxorubicin-Induced Osteoclast differentiation
Poudel, Sunil; Martins, Gil; Cancela, M. Leonor; Gavaia, PauloSecondary osteoporosis has been associated with cancer patients undertaking Doxorubicin (DOX) chemotherapy. However, the molecular mechanisms behind DOX-induced bone loss have not been elucidated. Molecules that can protect against the adverse effects of DOX are still a challenge in chemotherapeutic treatments. We investigated the effect and mechanism of DOX in osteoclast differentiation and used the Sirt 1 act...
Regular supplementation with antioxidants rescues Doxorubicin-Induced Bone defo...
Poudel, Sunil; Martins, Gil; Cancela, M. Leonor; Gavaia, PauloOsteoporosis is characterized by an abnormal bone structure with low bone mass and degradation of microarchitecture. Oxidative stress induces imbalances in osteoblast and osteoclast activity, leading to bone degradation, a primary cause of secondary osteoporosis. Doxorubicin (DOX) is a widely used chemotherapy drug for treating cancer, known to induce secondary osteoporosis. The mechanism underlying DOX-induced...