2 documents found, page 1 of 1
IL-17 triggers the onset of cognitive and synaptic deficits in early stages of ...
Cristiano Brigas, Maria Helena; Ribeiro, Miguel; Coelho, Joana E; Gomes, Rui; Gomez-Murcia, Victoria; Carvalho, Kevin; Faivre, EmilieNeuroinflammation in patients with Alzheimer's disease (AD) and related mouse models has been recognized for decades, but the contribution of the recently described meningeal immune population to AD pathogenesis remains to be addressed. Here, using the 3xTg-AD model, we report an accumulation of interleukin-17 (IL-17)-producing cells, mostly γδ T cells, in the brain and the meninges of female, but not male, mic...
Triggering of BDNF facilitatory action on neuromuscular transmission by adenosi...
Pousinha, Paula A.; Diógenes, Maria José; Ribeiro, Joaquim A.; Sebastião, Ana MMotor nerve terminals possess adenosine A2A receptors and brain derived neurotrophic factor (BDNF) TrkB receptors. In the present work we evaluated how BDNF actions on neuromuscular transmission would be influenced by adenosine A2A receptors activation. BDNF (20–100 ng/ml)on its own was devoid of effect on evoked endplate potentials (EPPs) recorded intracellularly from rat innervated diaphragms paralysed with t...