2 documents found, page 1 of 1
Nationwide study of drug resistance mutations in HIV-1 infected individuals und...
Santos-Pereira, Ana; Triunfante, Vera; Araújo, Pedro M. M.; Martins, Joana; Soares, Helena; Poveda, Eva; Souto, Bernardino; Osório, Nuno S.The success of antiretroviral treatment (ART) is threatened by the emergence of drug resistance mutations (DRM). Since Brazil presents the largest number of people living with HIV (PLWH) in South America we aimed at understanding the dynamics of DRM in this country. We analyzed a total of 20,226 HIV-1 sequences collected from PLWH undergoing ART between 2008–2017. Results show a mild decline of DRM over the yea...
Characterizing HIV-1 genetic subtypes and drug resistance mutations among child...
Yendewa, George A.; Lakoh, Sulaiman; Yendewa, Sahr A.; Bangura, Khadijah; Tabernilla, Andrés; Patiño, Lucia; Jiba, Darlinda F.; Vandy, Alren O.Human immunodeficiency virus (HIV) drug resistance (HIVDR) is widespread in sub-Saharan Africa. Children and pregnant women are particularly vulnerable, and laboratory testing capacity remains limited. We, therefore, used a cross-sectional design and convenience sampling to characterize HIV subtypes and resistance-associated mutations (RAMs) in these groups in Sierra Leone. In total, 96 children (age 2–9 years,...