4 documents found, page 1 of 1
Longitudinal assessment of migraine burden in resistant and refractory migraine...
Pensato, Umberto; Ornello, Raffaele; Rosignoli, Chiara; Caponnetto, Valeria; Onofri, Agnese; Braschinsky, Mark; Sved, Olga; Gil-Gouveia, RaquelBackground: Some individuals with migraine fail to respond adequately to preventive treatments, bearing most of migraine burden. The European Headache Federation (EHF) classifies these individuals into resistant migraine (ResM) or refractory migraine (RefM) according to treatment failures, debilitating headache days, and disease duration. We investigated the evolution of these categories over six months in pati...
Early use of erenumab vs nonspecific oral migraine preventives: the APPRAISE ra...
Pozo-Rosich, Patricia; Dolezil, David; Paemeleire, Koen; Stepien, Adam; Stude, Philipp; Snellman, Josefin; Arkuszewski, Michal; Stites, TracyImportance: Patients with migraine often cycle through multiple nonspecific preventive medications due to poor tolerability and/or inadequate efficacy leading to low adherence and increased disease burden. Objective: To compare the efficacy, tolerability, patient adherence, and patient satisfaction between erenumab and nonspecific oral migraine preventive medications (OMPMs) in patients with episodic migraine (...
European Headache Federation (EHF) consensus on the definition of effective tre...
Sacco, Simona; Lampl, Christian; Amin, Faisal Mohammad; Braschinsky, Mark; Deligianni, Christina; Uludüz, Derya; Versijpt, Jan; Ducros, AnneBACKGROUND: Triptans are migraine-specific acute treatments. A well-accepted definition of triptan failure is needed in clinical practice and for research. The primary aim of the present Consensus was to provide a definition of triptan failure. To develop this definition, we deemed necessary to develop as first a consensus definition of effective treatment of an acute migraine attack and of triptan-responder. M...
Analysis of shared heritability in common disorders of the brain
Anttila, Verneri; Bulik-Sullivan, Brendan; Finucane, Hilary K.; Walters, Raymond K.; Bras, Jose; Duncan, Laramie; Escott-Price, ValentinaDisorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common varian...