21 documents found, page 1 of 3
TGFβ in malignant canine mammary tumors: relation with angiogenesis, immunologi...
Carvalho, Maria Isabel; Carvalho, Ricardo Emanuel Silva; Prada, Justina; Pinto, Carla; Gregório, Hugo; Lobo, Luis; Pires, Isabel; Queiroga, Felisbina L.Transforming growth factor- (TGF) and FoxP3 regulatory T cells (Treg) are involved in human breast carcinogenesis. This topic is not well documented in canine mammary tumors (CMT). In this work, the tumoral TGF expression was assessed by immunohistochemistry in 67 malignant CMT and its correlation to previously determined FoxP3, VEGF, and CD31 markers and other clinicopathologic parameters was evaluated. The hi...
Animal tuberculosis: gross lesions and anatomopathological diagnosis
Quintas, Helder; Prada, Justina; Fontes, Maria da Conceição; Coelho, Ana Cláudia; Pires, IsabelAnimal tuberculosis (TB) is a zoonotic disease with worldwide distribution that can cause serious animal infections with economic and public health concerns. In its turn, human TB is currently one of the leading causes of death in the world due to a curable disease. Although the diagnosis demands microbiological culture confirmation, anatomopathological diagnosis of suggestive lesions often provides a presumpti...
Tuberculosis: integrated studies for a complex disease 2050
Rezaei, Nima; Hosseini, Nastaran-Sadat; Saghazadeh, Amene; Fateh, Abolfazl; Duse, Adriano; Ahmad, Aijaz; Braley, Alexander E.; Tahta, AlicanTuberculosis (TB) has been a disease for centuries with various challenges [1]. Like other places where challenges and opportunities come together, TB challenges were the inspiration for the scientific community to mobilize different groups for the purpose of interest. For example, with the emergence of drug resistance, there has been a huge volume of research on the discovery of new medicines and drug delivery...
Dextrin hydrogel loaded with a macroporous Bonelike® scaffold and dental pulp s...
Machado, A.; Pereira, Isabel; Pereira, José Eduardo; Maltez, Luís; Brandão, Ana; Alvites, Rui; Sousa, Ana Catarina; Branquinho, MarianaRegeneration of severe bone defects remains a challenge. A formulation of synthetic glass-reinforced hydroxyapatite bone substitute, Bonelike® Poro (BL®P), 250500 µm-diameter, with a dextrin-based hydrogel (HG), further loaded with human dental pulp stem cells (hDPSCs) with osteogenic differentiation ability, was tested for the management of critical-sized defects in an ovine model. Morphology, calcium release,...
Dextrin hydrogel loaded with a macroporous Bonelike® scaffold and dental pulp s...
Machado, Alexandra; Pereira, Isabel; Pereira, José Eduardo; Maltez, Luís; Brandão, Ana; Alvites, Rui; Sousa, Ana Catarina; Branquinho, MarianaRegeneration of severe bone defects remains a challenge. A formulation of synthetic glass-reinforced hydroxyapatite bone substitute, Bonelike® Poro (BL®P), 250–500 µm-diameter, with a dextrin-based hydrogel (HG), further loaded with human dental pulp stem cells (hDPSCs) with osteogenic differentiation ability, was tested for the management of critical-sized defects in an ovine model. Morphology, calcium release...
Injectable hydrogel as a carrier of vancomycin and a cathelicidin-derived pepti...
Machado, Fátima Alexandra Meira; Pereira, Isabel Sofia Melo; Silva, Vanessa; Pires, Isabel; Prada, Justina; Poeta, Patrícia; Costa, LuísA local drug delivery system that attempts to find a suitable balance between antimicrobial and regenerative actions was developed for osteomyelitis treatment (OM). This system combines the angiogenic and immunomodulatory peptide LLKKK18 (LL18) and vancomycin hydrochloride (VH), loaded into an injectable oxidized dextrin (ODEX)-based hydrogel (HG). In vitro cytotoxicity was analyzed in MC3T3-E1 pre-osteoblasts ...
The diagnostic challenges of ovine pulmonary adenocarcinoma
Quintas, Helder; Pires, Isabel; Garcês, Andreia; Prada, Justina; Silva, Filipe; Alegria, NunoOvine pulmonary adenocarcinoma (OPA), also known as sheep pulmonary adenomatosis and jaagsiekte, is a contagious pulmonary tumor of sheep, characterized by neoplastic proliferation of type II pneumocyte and club cells. OPA is induced by the oncogenic activity of the envelope glycoprotein (Env) of exogenous jaagsiekte sheep retrovirus (JSRV). This disease is associated with significant economic losses in numerou...
Combined use of chitosan and olfactory mucosa mesenchymal stem/stromal cells to...
Alvites, Rui D.; Branquinho, Mariana V.; Sousa, Ana C.; Amorim, Irina; Magalhães, Rui; João, Filipa; Almeida, Diogo; Amado, Sandra; Prada, JustinaPeripheral nerve injury remains a clinical challenge with severe physiological and functional consequences. Despite the existence of multiple possible therapeutic approaches, until now, there is no consensus regarding the advantages of each option or the best methodology in promoting nerve regeneration. Regenerative medicine is a promise to overcome this medical limitation, and in this work, chitosan nerve guid...
Regeneration of critical-sized defects, in a goat model, using a dextrin-based ...
Pereira, Isabel Sofia Melo; Pereira, José Eduardo; Maltez, Luís; Rodrigues, Alexandra; Rodrigues, Catarina; Oliveira, Manuela; Silva, Dina M.The development of injectable bone substitutes (IBS) have obtained great importance in the bone regeneration field, as a strategy to reach hardly accessible defects using minimally invasive techniques and able to fit to irregular topographies. In this scenario, the association of injectable hydrogels and bone graft granules is emerging as a well-established trend. Particularly, in situ forming hydrogels have ar...
Combined Use of Chitosan and Olfactory Mucosa Mesenchymal Stem/Stromal Cells to...
Alvites, R. D.; Branquinho, Mariana V.; Sousa, Ana C.; Amorim, Irina; Magalhães, Rui; João, Filipa; Almeida, Diogo; Amado, Sandra; Prada, JustinaPeripheral nerve injury remains a clinical challenge with severe physiological and functional consequences. Despite the existence of multiple possible therapeutic approaches, until now, there is no consensus regarding the advantages of each option or the best methodology in promoting nerve regeneration. Regenerative medicine is a promise to overcome this medical limitation, and in this work, chitosan nerve guid...