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Interferon gamma rebalances immunopathological signatures in chronic granulomat...
Bruno, M.; Kröger, C.; Ferreira, A. V.; Zhang, B.; Röring, R. J.; Liu, R.; van der Made, C. I.; van Rhijn, N.; Groh, L.; Klück, V.; Janssen, N. A. F.Chronic granulomatous disease (CGD) is a primary immunodeficiency characterized by recurrent life-threatening infections and hyperinflammatory complications. It is caused by mutations in the reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex and the consequent loss of reactive oxygen species (ROS) production. Recombinant human interferon gamma (rIFN-γ) prophylaxis reduces the risk of se...
Data: 2025
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Origem: RepositóriUM - Universidade do Minho