6 documents found, page 1 of 1
In vitro and in vivo evaluation of novel chromeno[2,3-d]pyrimidinones as therap...
Carvalho, Luísa; Lima, Fábio Pedroso de; Cerqueira, Mónica; Silva, Ana; Pontes, Olívia; Oliveira-Pinto, Sofia; Guerreiro, Sara; Costa, Marta D.Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, and the limited therapeutic options show poor efficacy in patients, associated to severe side effects and development of resistance. Considering that chromene-based scaffolds proved to be attractive candidates for cancer therapy, herein we prepared new chromeno[2,3-d]pyrimidinone derivatives by a simple two step procedure, sta...
Mitochondrial Dysfunction and Decreased Cytochrome c in Cell and Animal Models ...
Almeida, Filipa; Ferreira, Ildete L.; Naia, Luana; Marinho, Daniela; Vilaça-Ferreira, Ana Catarina; Costa, Marta D.; Duarte-Silva, SaraMitochondrial dysfunction has been described in many neurodegenerative disorders; however, there is less information regarding mitochondrial deficits in Machado-Joseph disease (MJD), a polyglutamine (polyQ) disorder caused by CAG repeat expansion in the ATXN3 gene. In the present study, we characterized the changes in mitochondrial function and biogenesis markers in two MJD models, CMVMJD135 (MJD135) transgenic...
Unravelling the anticancer potential of functionalized chromeno[2,3-b ] pyridin...
Oliveira-Pinto, Sofia; Pontes, Olivia; Lopes, Diogo; Marques, Maria Belém Sousa Sampaio; Costa, Marta D.; Carvalho, Luisa; Goncalves, Celine S.A selection of new chromeno[2,3-b]pyridines was prepared from chromenylacrylonitriles and N-substituted piperazines, using a novel and efficient synthetic procedure. The compounds were tested for their anticancer activity using breast cancer cell lines MCF-7, Hs578t and MDA-MB-231 and the non-neoplastic cell line MCF-10A for toxicity evaluation. In general, compounds showed higher activity towards the luminal b...
Antioxidant and neuroprotective effects of Hyptis suaveolens,Hyptis pectinata a...
Campos, Daniela V. -B.; Rios, R.; Bessa, C.; Costa, Marta D.; Teixeira-Castro, A.; Maciel, Patrícia; Dias, AlbertoThe increasing trend for the use of natural products as sources of pharmacologically active molecules has changed attitudes in the population. Given the existing demand, a credible scientific analysis and validation of the effect of these natural products is necessary. The genus Hyptis Jacq. (Lamiaceae) has about 300 species with wide distribution, among which Hyptis suaveolens, Hyptis pectinata and Hyptis marr...
Origin and spread of human mitochondrial DNA haplogroup U7
Sahakyan, Hovhannes; Hooshiar Kashani, Baharak; Tamang, Rakesh; Kushniarevich, Alena; Francis, Amirtharaj; Costa, Marta D.; Pathak, Ajai KumarHuman mitochondrial DNA haplogroup U is among the initial maternal founders in Southwest Asia and Europe and one that best indicates matrilineal genetic continuity between late Pleistocene hunter-gatherer groups and present-day populations of Europe. While most haplogroup U subclades are older than 30 thousand years, the comparatively recent coalescence time of the extant variation of haplogroup U7 (~16-19 thou...
Reconciling evidence from ancient and contemporary genomes: a major source for ...
Pereira, Joana B.; Costa, Marta D.; Vieira, Daniel; Pala, Maria; Bamford, Lisa; Harich, Nourdin; Cherni, Lotfi; Alshamali, Farida; Hatina, JiřiImportant gaps remain in our understanding of the spread of farming into Europe, due partly to apparent contradictions between studies of contemporary genetic variation and ancient DNA. It seems clear that farming was introduced into central, northern, and eastern Europe from the south by pioneer colonization. It is often argued that these dispersals originated in the Near East, where the potential source genet...