5 documents found, page 1 of 1
Pluronic® triblock copolymer-based nanoformulations for cancer therapy: A 10-ye...
de Castro, Karine Cappuccio; Coco, Julia Cedran; dos Santos, Érica Mendes; Ataide, Janaína Artem; Martinez, Renata MilianiThis paper provides a review of the literature on the use of Pluronic (R) triblock copolymers for drug encapsulation over the last 10 years. A special focus is given to the progress of drug delivery systems (e.g., micelles, liposomes, micro/nanoemulsions, hydrogels and nanogels, and polymersomes and niosomes); the beneficial aspects of Pluronic (R) triblock copolymers as biological response modifiers and as pha...
Advances in Pancreatic Cancer treatment by Nano-Based drug delivery systems
Viegas, Cláudia; Patrício, Ana B.; Prata, João; Fonseca, Leonor; Macedo, Ana S.; Duarte, Sofia O. D.; Fonte, PedroPancreatic cancer represents one of the most lethal cancer types worldwide, with a 5-year survival rate of less than 5%. Due to the inability to diagnose it promptly and the lack of efficacy of existing treatments, research and development of innovative therapies and new diagnostics are crucial to increase the survival rate and decrease mortality. Nanomedicine has been gaining importance as an innovative approa...
Traumatic pseudoaneurysm of the internal carotid artery causing epistaxis
Guimarães, Ana; Freire, Filipe; Vilela, Pedro; Branco, Gabriel; Lemos, Vitor; Prata, JoãoPost-traumatic pseudoaneurysms of the internal carotid artery are a rare cause of epistaxis, that can be life-threatening if not adequatelly managed.We report a case of a pseudoaneurysm of the carotid artery presenting with massive epistaxis, 11 years after craniofacial trauma. Coil embolization of the pseudoaneurysm was performed and the patient had no further episodes of epistaxis with no neurologic sequelae....
Stapes surgery for otosclerosis: retrospective analysis of outcomes
Guimarães, Ana; Hebe, Ana; Freire, Filipe; Prata, João; Veiga, GabãoObjective: To report hearing results of primary stapes surgery for otosclerosis in a consecutive series of 99 ears.Materials and methods: Retrospective chart review of eightyfour consecutive patients who underwent stapedectomy (99 ears) in a District General Hospital.Results: The mean 4-frequency (0.5, 1, 2 and 4 KHz) postoperative air-bone gap (ABG) was 5,4 dB, the preoperative minus postoperative ABG (hearing...
Extranodal NK/T-cell lymphoma nasal-type with an unusual location in the oropha...
Guimarães, Ana; Hebe, Ana; Freire, Filipe; Prata, João; Veiga, GabãoNK/T-cell lymphoma is a rare subtype of lymphoma of the sinonasal tract, previously known as lethal midline granuloma. lt is characterized by the progressive destructíon of midfacial structures.We report the case of a 43 year old woman with NK/T-cell lymphoma, nasal-type with an extremely unusual locatíon in the oropharynx. Despite of being rare, there are well defined therapeutíc modalitíes available in the ma...