5 documents found, page 1 of 1
Gingerol suppresses sepsis-induced acute kidney injury by modulating methylsulf...
Rodrigues, Francisco Adelvane de Paulo; Santos, Alan Diego da Conceição; Medeiros, Pedro Henrique Quintela Soares de; Prata, Mara de Moura GondimAcute kidney injury (AKI) and metabolic dysfunction are critical complications in sepsis syndrome; however, their pathophysiological mechanisms remain poorly understood. Therefore, we evaluated whether the pharmacological properties of 6-gingerol (6G) and 10-gingerol (10G) could modulate AKI and metabolic disruption in a rat model of sepsis (faecal peritonitis). Animals from the sham and AKI groups were intrape...
Infecção entérica por Escherichia coli enteroagregativa em crianças no semiárid...
Prata, Mara de Moura GondimEnteroaggregative Escherichia coli (EAEC) is one of the most prevalent enteric E. coli pathotype associated with diarrhea and asymptomatic infections in children less than five years of age living in developing countries. In the present study, we investigated the socioeconomic determinants related to the development of diarrhea or asymptomatic infection in the childhood population colonized by the EAEC, as well...
Clinical evaluation, biochemistry and genetic polymorphism analysis for the dia...
Ponte, Paulo Roberto Lins; Medeiros, Pedro Henrique Quintela Soares de; Havt, Alexandre; Caetano, Joselany Áfio; Cid, David A.C. CidIOBJECTIVE: This work aimed to evaluate and correlate symptoms, biochemical blood test results and single nucleotide polymorphisms for lactose intolerance diagnosis. METHOD: A cross-sectional study was conducted in Fortaleza, Ceará, Brazil, with a total of 119 patients, 54 of whom were lactose intolerant. Clinical evaluation and biochemical blood tests were conducted after lactose ingestion and blood samples wer...
Comparisons between myeloperoxidase, lactoferrin, calprotectin and lipocalin-2,...
Prata, Mara de Moura Gondim; Havt, Alexandre; Bolick, D. T.; Pinkerton, R.; Lima, A. A. M.; Guerrant, R. L.Fecal biomarkers have emerged as important tools to assess intestinal inflammation and enteropathy. The aim of this study was to investigate the correlations between the fecal markers, myeloperoxidase (MPO), lactoferrin (FL), calprotectin (FC) and lipocalin-2 (Lcn-2), and to compare differences by breastfeeding status as well as normalization by fecal protein or by fecal weight. Simultaneous, quantitative MPO, ...
Avaliação dos mecanismos de proliferação e tipos de morte celular na lesão indu...
Prata, Mara de Moura GondimEnteroaggregative Escherichia coli (EAEC) is among the most important agents associated with persistent diarrhea (DP) and was prevalent in studies in children in poor communities in the city of Fortaleza. EAEC cause intestinal injury and inflammation leading to DP and, when combined with malnutrition, can cause a cognitive deficit and infant growth impairment. The current study examined in vitro (IEC-6 and HEp-...