9 documents found, page 1 of 1
Effect of blueberry supplementation on a diet-induced rat model of prediabetes—...
Ferreira, Gonçalo; Vieira, Pedro; Alves, André; Nunes, Sara; Preguiça, Inês; Martins-Marques, Tânia; Ribeiro, Tânia; Girão, Henrique; Figueirinha, ArturBlueberries, red fruits enriched in polyphenols and fibers, are envisaged as a promising nutraceutical intervention in a plethora of metabolic diseases. Prediabetes, an intermediate state between normal glucose tolerance and type 2 diabetes, fuels the development of complications, including hepatic steatosis. In previous work, we have demonstrated that blueberry juice (BJ) supplementation benefits glycemic cont...
Biodistribution and intestinal inflammatory response following voluntary oral i...
Sousa, Adelaide; Azevedo, Rui; Costa, Vera Marisa; Oliveira, Sara; Preguiça, Inês; Viana, Sofia; Reis, Flávio; Almeida, Agostinho; Matafome, Paulo N.Silver nanoparticles (AgNP) are among the most widely commercialized nanomaterials globally, with applications in medicine and the food industry. Consequently, the increased use of AgNP in the food industry has led to an unavoidable rise in human exposure to these nanoparticles. Their widespread use raises concerns about potential hazards to human health, specifically their intestinal pro-inflammatory effects....
Blueberry Counteracts Prediabetes in a Hypercaloric Diet-Induced Rat Model and ...
Nunes, Sara; Viana, Sofia D.; Preguiça, Inês; Alves, André; Fernandes, Rosa; Teodoro, João S.; Matos, Patrícia; Figueirinha, Artur; Salgueiro, LígiaThe paramount importance of a healthy diet in the prevention of type 2 diabetes is now well recognized. Blueberries (BBs) have been described as attractive functional fruits for this purpose. This study aimed to elucidate the cellular and molecular mechanisms pertaining to the protective impact of blueberry juice (BJ) on prediabetes. Using a hypercaloric diet-induced prediabetic rat model, we evaluated the effe...
Blueberry counteracts prediabetes in a hypercaloric diet-induced rat model and ...
Nunes, Sara; Viana, Sofia D.; Preguiça, Inês; Alves, André; Fernandes, Rosa; Teodoro, João S.; Matos, Patrícia; Figueirinha, Artur; Salgueiro, LígiaThe paramount importance of a healthy diet in the prevention of type 2 diabetes is now well recognized. Blueberries (BBs) have been described as attractive functional fruits for this purpose. This study aimed to elucidate the cellular and molecular mechanisms pertaining to the protective impact of blueberry juice (BJ) on prediabetes. Using a hypercaloric diet-induced prediabetic rat model, we evaluated the effe...
Diet-Induced Rodent Models of Diabetic Peripheral Neuropathy, Retinopathy and N...
Preguiça, Inês; Alves, André; Nunes, Sara; Gomes, Pedro; Fernandes, Rosa; Viana, Sofia D.; Reis, FlávioUnhealthy dietary habits are major modifiable risk factors for the development of type 2 diabetes mellitus, a metabolic disease with increasing prevalence and serious consequences. Microvascular complications of diabetes, namely diabetic peripheral neuropathy (DPN), retinopathy (DR), and nephropathy (DN), are associated with high morbidity rates and a heavy social and economic burden. Currently, available thera...
Crescent-Like Lesions as an Early Signature of Nephropathy in a Rat Model of Pr...
Nunes, Sara; Alves, André; Preguiça, Inês; Barbosa, Adelaide; Vieira, Pedro; Mendes, Fernando; Martins, Diana; Viana, Sofia D.; Reis, FlávioDiabetic nephropathy (DN) is a major microvascular complication of diabetes. Obesity and hyperlipidemia, fueled by unhealthy food habits, are risk factors to glomerular filtration rate (GFR) decline and DN progression. Several studies recommend that diabetic patients should be screened early (in prediabetes) for kidney disease, in order to prevent advanced stages, for whom the current interventions are clearly ...
Blueberry Consumption Challenges Hepatic Mitochondrial Bioenergetics and Elicit...
Nunes, Sara; Viana, Sofia D.; Preguiça, Inês; Alves, André; Fernandes, Rosa; Teodoro, João S.; Figueirinha, Artur; Salgueiro, Lígia; Silva, SaraAn emergent trend of blueberries' (BB) "prophylactic" consumption, due to their phytochemicals' richness and well-known health-promoting claims, is widely scaled-up. However, the benefits arising from BB indiscriminate intake remains puzzling based on incongruent preclinical and human data. To provide a more in-depth elucidation and support towards a healthier and safer consumption, we conducted a translation-m...
Crescent-like lesions as an early signature of nephropathy in a rat model of pr...
Nunes, Sara; Alves, André; Preguiça, Inês; Barbosa, Adelaide; Vieira, Pedro; Mendes, Fernando; Martins, Diana; Viana, Sofia; Reis, FlávioDiabetic nephropathy (DN) is a major microvascular complication of diabetes. Obesity and hyperlipidemia, fueled by unhealthy food habits, are risk factors to glomerular filtration rate (GFR) decline and DN progression. Several studies recommend that diabetic patients should be screened early (in prediabetes) for kidney disease, in order to prevent advanced stages, for whom the current interventions are clearly ...
Blueberry consumption challenges hepatic mitochondrial bioenergetics and elicit...
Nunes, Sara; Viana, Sofia D.; Preguiça, Inês; Alves, André; Fernandes, Rosa; Teodoro, João S.; Figueirinha, Artur; Salgueiro, Lígia; Silva, SaraAn emergent trend of blueberries’ (BB) “prophylactic” consumption, due to their phytochemicals’ richness and well-known health-promoting claims, is widely scaled-up. However, the benefits arising from BB indiscriminate intake remains puzzling based on incongruent preclinical and human data. To provide a more in-depth elucidation and support towards a healthier and safer consumption, we conducted a translation-m...