73 documents found, page 1 of 8
Enhancement of acetate-induced apoptosis of colorectal cancer cells by cathepsi...
Alves, Sara; Santos-Pereira, Cátia; Oliveira, Cláudia S. F.; Preto, Ana; Chaves, Susana R.; Côrte-Real, ManuelaColorectal cancer (CRC) is a leading cause of death worldwide. Conventional therapies are available with varying effectiveness. Acetate, a short-chain fatty acid produced by human intestinal bacteria, triggers mitochondria-mediated apoptosis preferentially in CRC but not in normal colonocytes, which has spurred an interest in its use for CRC prevention/therapy. We previously uncovered that acetate-induced mitoc...
Anticancer activity of benzo[a]phenoxazine compounds promoting lysosomal dysfun...
Ferreira, João Carlos Canossa; Gonçalves, M. Sameiro T.; Preto, Ana; Sousa, Maria JoãoSpecific cancer therapy remains a problem to be solved. Breast and colorectal cancer are among the cancers with the highest prevalence and mortality rates. Although there are some therapeutic options, there are still few effective agents for those cancers, which constitutes a clinical problem that requires further research efforts. Lysosomes play an important role in cancer cells’ survival, and targeting lysoso...
Targeting lysosomes in colorectal cancer: exploring the anticancer activity of ...
Ferreira, João C. C.; Granja, Sara; Almeida, Ana F.; Baltazar, Fátima; Gonçalves, M. Sameiro T.; Preto, Ana; Sousa, Maria JoãoColorectal cancer (CRC) has been ranked as one of the cancer types with a higher incidence and one of the most mortal. There are limited therapies available for CRC, which urges the finding of intracellular targets and the discovery of new drugs for innovative therapeutic approaches. In addition to the limited number of effective anticancer agents approved for use in humans, CRC resistance and secondary effects...
Novel benzo[α]phenoxazinium chlorides functionalized with sulfonamide groups as...
Ferreira, J. C. C.; Sousa, Rui Pedro Carvalho Lima; Preto, Ana; Sousa, Maria João; Gonçalves, M. Sameiro T.The demand for new fluorophores for different biological target imaging is increasing. Benzo[<i>a</i>]phenoxazine derivatives are fluorochromophores that show promising optical properties for bioimaging, namely fluorescent emission at the NIR of the visible region, where biological samples have minimal fluorescence emission. In this study, six new benzo[<i>a</i>]phenoxazinium chlorides possessing sulfonamide gr...
Targeting lysosomes in colorectal cancer: exploring the anticancer activity of ...
Ferreira, João C. C.; Granja, Sara Costa; Almeida, Ana F.; Baltazar, Fátima; Gonçalves, M. Sameiro T.; Preto, Ana; Sousa, Maria JoãoColorectal cancer (CRC) has been ranked as one of the cancer types with a higher incidence and one of the most mortal. There are limited therapies available for CRC, which urges the finding of intracellular targets and the discovery of new drugs for innovative therapeutic approaches. In addition to the limited number of effective anticancer agents approved for use in humans, CRC resistance and secondary effects...
New ruthenium-cyclopentadienyl complexes affect colorectal cancer hallmarks sho...
Brás, Ana Rita; Fernandes, Pedro; Moreira, Tiago; Morales-Sanfrutos, Julia; Sabidó, Eduard; Antunes, Alexandra M. M.; Valente, Andreia; Preto, AnaColorectal cancer (CRC) is among the most deadly cancers worldwide. Current therapeutic strategies have low success rates and several side effects. This relevant clinical problem requires the discovery of new and more effective therapeutic alternatives. Ruthenium drugs have arisen as one of the most promising metallodrugs, due to their high selectivity to cancer cells. In this work we studied, for the first tim...
Modulation of the tumor microenvironment by microbiota-derived short-chain fatt...
Gomes, Sara; Rodrigues, Ana Catarina; Pazienza, Valerio; Preto, AnaFinding new therapeutic approaches towards colorectal cancer (CRC) is of increased relevance, as CRC is one of the most common cancers worldwide. CRC standard therapy includes surgery, chemotherapy, and radiotherapy, which may be used alone or in combination. The reported side effects and acquired resistance associated with these strategies lead to an increasing need to search for new therapies with better effi...
Colon microbiota modulation by dairy-derived diet: new strategy for prevention ...
Gomes, Sara; Teixeira-Guedes, Catarina; Silva, Elisabete; Baltazar, Fátima; Preto, AnaAn unbalanced diet is one of the well-known risk factors for the development of colorectal cancer (CRC). This type of cancer is currently the main cause of cancer-related deaths worldwide, urging the need for new and more effective preventive and therapeutic approaches. It is already known that CRC patients have alterations in the microbial community and metabolism. In this regard, a concept that has been recen...
Microbiota-derived short-chain fatty acids: new road in colorectal cancer therapy
Gomes, Sara; Baltazar, Fátima; Silva, Elisabete; Preto, AnaThe colon microbiota is an important player in colorectal cancer (CRC) development, which is responsible for most of the cancer-related deaths worldwide. During carcinogenesis, the colon microbiota composition changes from a normobiosis profile to dysbiosis, interfering with the production of short-chain fatty acids (SCFAs). Each SCFA is known to play a role in several biological processes but, despite their re...
Cytoskeleton disruption by the metabolic inhibitor 3-bromopyruvate: implication...
Azevedo-Silva, J.; Tavares-Valente, D.; Almeida, A.; Queiros, O.; Baltazar, Fátima; Ko, Y. H.; Pedersen, P. L.; Preto, Ana; Casal, MargaridaThe small molecule 3-bromopyruvate (3BP), is an anticancer molecule that acts by hindering glycolysis and mitochondrial function leading to energy depletion and consequently, to cell death. In this work we have focused on understanding how the glycolytic inhibition affects cancer cell structural features. We showed that 3BP leads to a drastic decrease in the levels of beta-actin and alpha-tubulin followed by di...