13 documents found, page 1 of 2
Evaluation of the anticancer potential of the macrofungus Pisolithus arhizus my...
Santos, Germana; Preto, Marco; Vasconcelos, Vítor; Martins, Rosário; Oliveira, Rui S.; Martins, RosarioMacrofungi produce remarkable biomedical products that can make a significant contribution to health. Pisolithus arhizus is a fungal species of the phylum Basidiomycota. It is mainly found in association with the roots of some trees species, establishing a mutualistic relationship with them, facilitating the absorption of nutrients from the soil in exchange for carbohydrates produced by the host plant. As recen...
Exploring the bioactive potential of Pisolithus (Basidiomycota): comprehensive ...
S. Oliveira, Rui; Preto, Marco; Santos, Germana; Silva, Ana Margarida; Vasconcelos, Vitor; Martins, RosárioAddressing pressing health concerns, modern medical research seeks to identify new antimicrobials to combat drug resistance, novel molecules for cancer treatment, and antioxidants for inflammation-related diseases. Pisolithus (Basidiomycota) is a ubiquitous and widely distributed fungal genus in forest ecosystems, known for establishing ectomycorrhizal associations with a range of host plants, enhancing their g...
Tracing the path between mushrooms and Alzheimer's disease-a literature review
Silva, Ana Margarida; Preto, Marco; Grosso, Clara; Vieira, Monica; Delerue-Matos, Cristina; Vasconcelos, Vítor; Reis, Mariana; Barros, LillianAlzheimer's disease (AD) is well-known among neurodegenerative diseases for the decline of cognitive functions, making overall daily tasks difficult or impossible. The disease prevails as the most common form of dementia and remains without a well-defined etiology. Being considered a disease of multifactorial origin, current targeted treatments have only managed to reduce or control symptoms, and to date, only ...
Tracing the path between mushrooms and Alzheimer’s Disease—a literature review
Silva, Ana Margarida; Preto, Marco; Grosso, Clara; Vieira, Mónica; Delerue-Matos, Cristina; Vasconcelos, Vitor; Reis, Mariana; Barros, LillianAlzheimer’s disease (AD) is well-known among neurodegenerative diseases for the decline of cognitive functions, making overall daily tasks difficult or impossible. The disease prevails as the most common form of dementia and remains without a well-defined etiology. Being considered a disease of multifactorial origin, current targeted treatments have only managed to reduce or control symptoms, and to date, only ...
Exploitation of filamentous and picoplanktonic cyanobacteria for cosmetic appli...
Morone, Janaína; Lopes, Graciliana; Preto, Marco; Vasconcelos, Vítor; Martins, RosárioThe use of natural products in skin care formulations gained interest as a concern formodern societies. The undesirable side effects of synthetic compounds, as well as the associatedenvironmental hazards, have driven investigation on photosynthetic organisms as sustainable sourcesof effective and environmentally friendly ingredients. The use of natural extracts in cosmetics hasbeen highlighted and, along with p...
Phytochemical profile, antioxidant activity and cytotoxicity against keratinocy...
Morone, Janaína; Lopes, Graciliana; Preto, Marco; Vasconcelos, Vítor; Martins, RosárioCombining the increase demand for natural products in skin care formulations, and the bioactive arsenal of cyanobacteria, we aimed with this study to evaluate the potential of a 70% ethanolic extract of picocyanobacteria strains of the genera Cyanobium and Synechocystis for skin care applications.
A natural oxadiazine isolated from cyanobacteria kills cancer cells in multicel...
Sousa, Maria Lígia; Preto, Marco; Martins, Rosário; Vasconcelos, Vítor; Linder, Stig; Urbatzka, RalphCyanobacteria are versatile microorganisms that ubiquitously inhabit terrestrial and aquatic ecosystems. They adapt to external threats by mainly producing secondary metabolites. Therefore, cyanobacteria have been recognized as producer of natural products with potential biotechnological applications, such as bioplastics, antifouling, antibiotics, antiprotozoal or anticancer treatment.
Anticancer potential of spores of the soil fungus Pisolithus tinctorius
Oliveira, Rui S.; Alves, Ricardo; Preto, Marco; Martins, RosárioCancer is one of the major causes of death worldwide being the search for new anticancer drugs essential for the treatment of this disease. The sporocarps of the soil fungus Pisolithus tinctorius contain pisosterol, a triterpene that has been shown to have antitumor activity against some cancer cell lines. Nevertheless, no studies have focused on the anticancer potential of other structures such as spores, and ...
Generation of spheroids of cancer cells for screening of antitumour activity of...
Sousa, Maria Lígia; Preto, Marco; Vasconcelos, Vítor; Martins, Rosário; Linder, Stig; Leão, Pedro; Urbatzka, RalphThe use of 3D cell culture for modelling cancer research is gaining interest, and in particular for screening of bioactive compounds. In the presented work, three compounds isolated from cyanobacteria and 92 chromatographic fractions obtained from crude organic extracts of 28 cyanobacterial strains from the Portuguese coast were tested on multicellular spheroids generated from the human cell lines HCT116 (colon...
Cytotoxicity induced by extracts of pisolithus tinctorius spores on human cance...
Alves, Ricardo; Preto, Marco; Vasconcelos, Vitor; Oliveira, Rui; Martins, RosárioFungi have been considered a potential source of natural anticancer drugs. However, studies on these organisms have mainly focused on compounds present in the sporocarp and mycelium. The aim of this study was to assess the anticancer potential of fungal spores using a bioassay-guided fractionation with cancer and normal cell lines. Crude extracts from spores of the basidiomycetous fungus Pisolithus tinctorius w...