4 documents found, page 1 of 1
Screening for Colorectal Cancer Leading into a New Decade: The “Roaring ‘20s” f...
Almeida-Lousada, Hélder; Mestre, André; Ramalhete, Sara; Price, Aryeh J.; Mello, Ramon Andrade de; Marreiros, Ana D.; Neves, Ricardo Pires dasColorectal cancer (CRC) has an important bearing (top five) on cancer incidence and mortality in the world. The etiology of sporadic CRC is related to the accumulation of genetic and epigenetic alterations that result in the appearance of cancer hallmarks such as abnormal proliferation, evasion of immune destruction, resistance to apoptosis, replicative immortality, and others, contributing to cancer promotion,...
Screening for colorectal cancer leading into a new decade: the “Roaring ‘20s” f...
Almeida-Lousada, Hélder; Mestre, André; Ramalhete, Sara Maria Ventura; Price, Aryeh J.; De Mello, Ramon Andrade; Marreiros, AnaColorectal cancer (CRC) has an important bearing (top five) on cancer incidence and mortality in the world. The etiology of sporadic CRC is related to the accumulation of genetic and epigenetic alterations that result in the appearance of cancer hallmarks such as abnormal proliferation, evasion of immune destruction, resistance to apoptosis, replicative immortality, and others, contributing to cancer promotion,...
Combined genetic and epigenetic alterations of the TERT promoter affect clinica...
Leão, Ricardo; Lee, Donghyun; Figueiredo, Arnaldo; Hermanns, Thomas; Wild, Peter; Komosa, Martin; Lau, Irene; Mistry, Mathew; Nunes, Nuno MiguelIn urothelial bladder cancer (UBC), risk stratification remains an important unmet need. Limitless self-renewal, governed by TERT expression and telomerase activation, is crucial for cancer progression. Thus, telomerase activation through the interplay of mutations (TERTpMut ) and epigenetic alterations in the TERT promoter may provide further insight into UBC behavior. Here, we investigated the combined effect...
The TERT hypermethylated oncologic region predicts recurrence and survival in p...
Faleiro, Inês; Apolónio, Joana; Price, Aryeh J.; De Mello, Ramon Andrade; Roberto, Vânia; Tabori, Uri; Castelo-Branco, PedroAim: We explore the biomarker potential of the TERT hypermethylated oncologic region (THOR) in pancreatic cancer. Materials & methods: We assessed the methylation status of THOR using the cancer genome atlas data on the cohort of pancreatic cancer (n = 193 patients). Results: THOR was significantly hypermethylated in pancreatic tumor tissue when compared with the normal tissue used as control (p < 0.0001). Also...