6 documents found, page 1 of 1
Non-Invasive versus Invasive Assessment of Portal Hypertension in Chronic Liver...
Gaspar,Rui; Macedo,GuilhermeAbstract Background: Cirrhosis is one of the major causes of morbidity and mortality worldwide and the second leading cause of digestive disease mortality. Portal hypertension is the main driver of cirrhosis-related complications such as ascites and variceal bleeding. Portal hypertension is defined as a hepatic venous pressure gradient >5 mm Hg, although it is clinically significant and associated with clinical c...
Percutaneous Endoscopic Gastrostomy Placement under NIV in Amyotrophic Lateral ...
Gaspar,Rui; Ramalho,Rosa; Coelho,Rosa; Andrade,Patrícia; Goncalves,Miguel R.; Macedo,GuilhermeAbstract Introduction: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with an inexorably progressive course which leads to a progressive neuromuscular weakness. Weight loss is one of the major bad prognostic factors in ALS. The placement of percutaneous endoscopic gastrostomy (PEG) is of paramount importance in patients with dysphagia to improve the disease outcomes, although some fear exis...
A Rare Cause of Acute Liver Failure: Diffuse Liver Metastization of Merkel Cell...
Santos,Ana Luísa; Pereira,Vítor Magno; Coelho,Rosa; Gaspar,Rui; Cardoso,Hélder; Lopes,Joanne; Macedo,GuilhermeThe authors describe a case of a 76-year-old male with a medical history of Merkel cell carcinoma (MCC) of the right lower eyelid. He was admitted to the emergency department due to abdominal pain in the right hypochondrium, nauseas, asthenia, and choluria with 3 days of evolution. Biochemical liver workup revealed a cytocholestase pattern as well as a prolonged prothrombin time. After admission, the patient de...
Mixed Adenoneuroendocrine Tumor of the Rectum in an Ulcerative Colitis Patient
Gaspar,Rui; Santos-Antunes,João; Marques,Margarida; Liberal,Rodrigo; Melo,Daniel; Pereira,Pedro; Lopes,Susana; Macedo,GuilhermePatients with inflammatory bowel disease present a higher risk of colorectal cancer, especially patients with a high degree of disease activity. Although rare, carcinoid tumors can also be associated with inflammatory bowel disease. Mixed adenoneuroendocrine tumor is defined as a neoplasm with dual differentiation (neuroendocrine and adenoma) with each component accounting for at least 30% of the tumor. We pres...
Evaluation of Small-Bowel Patency in Crohns Disease: Prospective Study with a ...
Silva,Marco; Cardoso,Hélder; Cunha,Rui; Peixoto,Armando; Gaspar,Rui; Gomes,Sara; Santos,Ana Luísa; Lopes,Susana; Macedo,GuilhermeBackground and Purpose: Patency capsule (PC) examination is usually performed - previously to capsule endoscopy - to evaluate small-bowel patency in patients with established Crohns disease (CD). The reported PC retention rate is significantly higher than expected. Our aims were to assess small-bowel patency, to determine the precise location of the retained PC in patients with CD, and to determine the false p...
Diagnostic Accuracy of Controlled Attenuation Parameter for Detecting Hepatic S...
Andrade,Patrícia; Rodrigues,Susana; Rodrigues-Pinto,Eduardo; Gaspar,Rui; Lopes,Joanne; Lopes,Susana; Macedo,GuilhermeIntroduction: Controlled attenuation parameter (CAP), measured by transient elastography, has been suggested as a noninvasive method for the detection and quantification of steatosis. We aimed to assess the accuracy of CAP to detect steatosis in patients with chronic liver disease (CLD) compared with liver histology and to evaluate factors that correlate with the CAP value. Methods: Patients with CLD who underw...