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Recomendações Portuguesas para Utilização de Terapêuticas Biológicas em Criança...

Santos, Maria José; Conde, Marta; Mourão, Ana Filipa; Ramos, Filipa Oliveira; Cabral, Marta; Brito, Iva; Ramos, Margarida Paula

Introduction: To provide evidence-based guidance for the rati onal and safe prescripti on of biological therapies in children and adolescents with juvenile idiopathic arthriti s (JIAs), considering the latest available evidence and the new licensed biologics. Methods: Rheumatologists and Pediatricians with experti se in Pediatric Rheumatology updated the recommendati ons endorsed by the Portuguese Society of Rh...


Effectiveness and long-term retention of anti-tumour necrosis factor treatment ...

Mourao, Ana F.; Santos, Maria J.; Melo Gomes, Jose A.; Martins, Fernando M.; Mendonca, Silvia C.; Ramos, Filipa Oliveira; Fernandes, Susana

Methods. We prospectively collected patient and disease characteristics from patients with JIA who started biological therapy. Adverse events were collected during the follow-up period. Predictors of response at 1 year and drug retention rates were assessed at 4 years of treatment for the first biologic agent.Results. A total of 812 JIA patients [65% females, mean age at JIA onset 6.9 years (s.d. 4.7)], 227 rec...


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