Vitamin D is a fundamental regulator of host defences by activating genes related to innate and adaptive immunity. Previous research shows a correlation between the levels of vitamin D in patients infected with SARS-CoV-2 and the degree of disease severity. This work investigates the impact of the genetic background related to vitamin D pathways on COVID-19 severity. For the first time, the Portuguese populatio...
Abstract Background: Ocriplasmin is a serine protease approved for the treatment of symptomatic vitreomacular traction (VMT). Post-marketing experience has revealed safety concerns. Materials and Methods: Retrospective case report. Clinical and surgical data were analyzed. Results: We report a case of intraindividual response to bilateral ocriplasmin injection in a 70 year-old female patient with symptomatic v...
Objectives: To describe our experience with a coronavirus disease 2019 (COVID-19) outbreak within a large rheumatology department early in the pandemic. Methods: Symptomatic and asymptomatic healthcare workers (HCWs) had a naso-oropharyngeal swab for detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and were followed clinically. Reverse transcription polymerase-chain reaction (RT-PCR) wa...
Introdução: A hipertensão ocular (HTO) pós-operatória é uma complicação subestimada pela maioria dos cirurgiões vítreo-retinianos, tendo elevada incidência e potencial para um mau resultado funcional. Contrastando com a maioria dos estudos, avaliámos esta problemática numa única patologia - o descolamento de retina (DR) regmatógeno. Métodos: Avaliação retrospetiva de 143 doentes submetidos a cirurgia de DR regm...
Introdução: A hemodiálise (HD), técnica substitutiva da função renal utilizada em doentes com doença renal crónica terminal (DRCT) está associada a alterações hemodinâmicas bem descritas. O estudo da resposta de tecidos altamente vascularizados como a retina e coroideia a estas alterações hemodinâmicas pode permitir melhorar o conhecimento da fisiologia da circulação ocular. O objectivo deste estudo foi avaliar...
Purpose: to report an unusual case of Leber's Hereditary Optic Neuropathy (LHON) and simultaneous ocular hypertension. Methods: case report of a 40 year-old patient, who complained of recently noticed vision loss in the right eye (OD). Results: OD presented with simultaneous ocular hypertension, optic atrophy and total cupping, leading to the suspicion of glaucomatous optic atrophy. Progressive vision loss was...