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Thiamine compounds alleviate oxidative stress, over-expression of pro-inflammat...
Strekalova, Tatyana; Gorlova, Anna; Nunes, João; Litavrin, Aleksandr; Munter, Johannes P. M. de; Lyundup, Alexei; Umriukhin, Aleksei; Proshin, AndreyExperiences of life-threatening stimuli can induce post-traumatic stress disorder (PTSD), which is associated with long-lasting behavioral and neurochemical abnormalities. Despite its increased global incidence, the current treatment options for PTSD remain limited, highlighting the need for novel therapeutic strategies. As oxidative stress and neuroinflammation contribute to PTSD, the use of powerful antioxida...
Predation stress causes excessive aggression in female mice with partial geneti...
Svirin, Evgeniy; Veniaminova, Ekaterina; Nunes, João; Gorlova, Anna; Umriukhin, Aleksei; Kalueff, Allan V.; Proshin, Andrey; Anthony, Daniel C.The interaction between brain serotonin (5-HT) deficiency and environmental adversity may predispose females to excessive aggression. Specifically, complete inactivation of the gene encoding tryptophan hydroxylase-2 (Tph2) results in the absence of neuronal 5-HT synthesis and excessive aggressiveness in both male and female null mutant (Tph2-/-) mice. In heterozygous male mice (Tph2+/-), there is a moderate red...