8 documents found, page 1 of 1
A novel 4-aminoquinoline chemotype with multistage antimalarial activity and la...
Ferreira, Letícia Tiburcio; Cassiano, Gustavo Capatti; Alvarez, Luis Carlos Salazar; Okombo, John; Calit, Juliana; Fontinha, Diana; Gil-Iturbe, EvaFunding Information: This study was supported by Fundação de Amparo à Pesquisa do Estado de São Paulo - FAPESP (2019/02171-3 and 2021/13809-9 to LTF, 2017/18611-7 to FTMC, 2021/06769-0 to DYB, and 2018/24878-9 to JC), Conselho Nacional de Desenvolvimento Científico e Tecnológico – CNPq (441038/2020-4 and 440373/2022-0 to CHA, and 162117/2018-3 to LCSA), and the National Institutes of Health – NIH (R01 AI124678 ...
High efficacy of chloroquine-derived bile salts in Pluronic F127 micelles again...
Silva, Ana Teresa; Oliveira, Isabel S.; Morais, Inês; Santana, Sofia; Workneh, Eyob A.; Prudêncio, Miguel; Nogueira, Fátima; Ferraz, RicardoFunding Information: The authors thank Funda\u00E7\u00E3o para a Ci\u00EAncia e Tecnologia/Minist\u00E9rio da Educa\u00E7\u00E3o e Ci\u00EAncia \u2013 FCT/MEC, for PT national funds through the project CIRCNA/BRB/0281/2019. FCT/MCE is further acknowledged for supporting the Research Units LAQV-REQUIMTE (LA/P/0008/2020, UIDP/50006/2020 and UIDB/50006/2020), CIQUP (UIDB/00081/2020), IMS (LA/P/0056/2020), and GHTM...
Innovative Multistage ML-QSAR Models for Malaria
Borba, Joyce V. B.; Salazar-Alvarez, Luis Carlos; Ferreira, Letícia Tiburcio; Silva-Mendonça, Sabrina; Silva, Meryck Felipe Brito da; Sanches, Igor H.Funding Information: The Article Processing Charge for the publication of this research was funded by the Coordination for the Improvement of Higher Education Personnel - CAPES (ROR identifier: 00x0ma614). The authors would like to thank the funding agencies CNPq (441038/2020-4), CAPES-STINT (88881.304811/2018-01), FAPEG (202010267000272), FAPESP (Grants 2017/18611-7, 2021/06769-0, and 2021/06769-0), Instituto ...
Corrigendum to
Silva, Ana Teresa; Oliveira, Isabel S.; Gomes, Joana M.; Aguiar, Luísa; Fontinha, Diana; Duarte, Denise Maria Figueiredo Araújo; Nogueira, FátimaScheme 1 and Figure 1 in this article were incorrect. The correct ones, and their respective captions, follow: 1 Scheme (Figure presented.) Synthesis route to PQ-derived organic salts 3a–g. (i) 1a (1 molar equivalent, eq), 2a–g (1 eq), methanol (MeOH), room temperature (RT), 30 min. 1 Figure (Figure presented.) Surface tension plots and cmc determination, at 25 °C, of aqueous CTAB/SAIL mixtures: A) surface tens...
Facile Access to Structurally Diverse Antimalarial Indoles Using a One-Pot A3 C...
da Silva, Gustavo; Luz, André F.S.; Duarte, Denise; Fontinha, Diana; Silva, Vera L.M.; Almeida Paz, Filipe A.; Madureira, Ana M.; Simões, SandraFunding Information: . The authors acknowledge the financial support provided by Fundação para a Ciência e a Tecnologia (FCT Portugal) through the PhD grant research project SFRH/BD/103412/2014 and projects PTDC/MED‐QUI/30021/2017, PTDC/MED‐CAR/31322/2017 and PTDC/SAU‐TOX/32515/2017, and the research unit GHTM (UID/Multi/04413/2013 and GHTM‐UID/04413/2020). We thank MR4 for providing us with malaria parasites c...
A simple polystyrene microfluidic device for sensitive and accurate SERS-based ...
Oliveira, Maria João; Caetano, Soraia; Dalot, Ana; Sabino, Filipe; Calmeiro, Tomás R.; Fortunato, Elvira; Martins, Rodrigo; Pereira, EuláliaM. P. acknowledges “la Caixa” Foundation for Grant HR21-848. Publisher Copyright: © 2023 The Royal Society of Chemistry.; Early and accurate detection of infection by pathogenic microorganisms, such as Plasmodium, the causative agent of malaria, is critical for clinical diagnosis and ultimately determines the patient's outcome. We have combined a polystyrene-based microfluidic device with an immunoassay which u...
Drug-Derived Surface-Active Ionic Liquids
Silva, Ana Teresa; Oliveira, Isabel S.; Gomes, Joana; Aguiar, Luísa; Fontinha, Diana; Duarte, Denise; Nogueira, Fátima; Prudêncio, MiguelFunding Information: The authors thank Fundação para a Ciência e Tecnologia (FCT, Portugal), for funding Research Units LAQV‐REQUIMTE (UIDB/50006/2020), CIQUP (UIDB/00081/2020), and GHTM (UID/Multi/04413/2013), and for project grant PTDC/BTM‐SAL/29786/2017. ATS thanks FCT and Sociedade Portuguesa de Química (SPQ, Portugal) for her doctoral grant SFRH/BD/150649/2020 Publisher Copyright: © 2021 Wiley-VCH GmbH; In...
Violacein-Induced Chaperone System Collapse Underlies Multistage Antiplasmodial...
Tavella, Tatyana Almeida; Da Silva, Noeli Soares Melo; Spillman, Natalie; Kayano, Ana Carolina Andrade Vitor; Cassiano, Gustavo CapattiAntimalarial drugs with novel modes of action and wide therapeutic potential are needed to pave the way for malaria eradication. Violacein is a natural compound known for its biological activity against cancer cells and several pathogens, including the malaria parasite, Plasmodium falciparum (Pf). Herein, using chemical genomic profiling (CGP), we found that violacein affects protein homeostasis. Mechanisticall...