6 documents found, page 1 of 1
A typological study of Portuguese mortality from non-communicable diseases
Nascimento, AP; Prudêncio, C; Vieira, M; Pimenta, R; Bacelar-Nicolau, HThe most common non-communicable diseases, such as cardiovascular diseases and cancer, are a problem in global and national growth. The World Health Organization considers it a priority to study the specific causes of these diseases for trend monitoring. The aim of this paper is to identify a hierarchy of clusters of Portuguese mortality by noncommunicable diseases using the agglomerative hierarchical cluster a...
The impact of [c16pyr][amp] on the aggressiveness in breast and prostate cancer...
Vieira, FQ; Marques-Magalhães, Â; Miranda-Gonçalves, V; Ferraz, R; Vieira, M; Prudêncio, C; Jerónimo, C; Silva, RABreast (BrCa) and prostate (PCa) cancers are the most common malignancies in women and men, respectively. The available therapeutic options for these tumors are still not curative and have severe side effects. Therefore, there is an urgent need for more effective antineoplastic agents. Herein, BrCa, PCa, and benign cell lines were treated with two ionic liquids and two quinoxalines and functional experiments we...
Cinnamic acid conjugates in the rescuing and repurposing of classical antimalar...
Silva, AT; Bento, CM; Pena, AC; Figueiredo, LM; Prudêncio, C; Aguiar, L; Silva, T; Ferraz, R; Gomes, MS; Teixeira, C; Gomes, PCinnamic acids are compounds of natural origin that can be found in many different parts of a wide panoply of plants, where they play the most diverse biological roles, often in a conjugated form. For a long time, this has been driving Medicinal Chemists towards the investigation of the therapeutic potential of natural, semi-synthetic, or fully synthetic cinnamic acid conjugates. These efforts have been steadil...
Synthesis and antibacterial activity of ionic liquids and organic salts based o...
Ferraz, R; Silva, D; Dias, AR; Dias, V; Santos, MM; Pinheiro, L; Prudêncio, C; Noronha, JP; Petrovski, Ž; Branco, LCThe preparation and characterization of ionic liquids and organic salts (OSILs) that contain anionic penicillin G [secoPen] and amoxicillin [seco-Amx] hydrolysate derivatives and their in vitro antibacterial activity against sensitive and resistant Escherichia coli and Staphylococcus aureus strains is reported. Eleven hydrolyzed ß-lactam-OSILs were obtained after precipitation in moderate-to-high yields via the...
Recycling old antibiotics with ionic liquids
Prudêncio, C; Vieira, M; der Auweraer, S; Ferraz, RAntibiotics are considered one of the great “miracles” of the 20th century. Now in the 21st century in the post-antibiotic era, the miracle is turning into a nightmare, due to the growing problem of the resistance of microorganisms to classic antimicrobials and the non-investment by the pharmaceutical industry in new antimicrobial agents. Unfortunately, the current COVID-19 pandemic has demonstrated the global ...
ESBL and AmpC ß-lactamases in clinical strains of Escherichia coli from Serra d...
Oliveira, C; Amador, P; Prudêncio, C; Tomaz, C; Tavares-ratado, P; Fernandes, RBackground and Objectives: Given the considerable spatial, temporal, and ecological factors, heterogeneity, which affects emergency response, persistence, and dissemination of genetic determinants that confer microorganisms their resistance to antibiotics, several authors claim that antibiotics’ resistance must be perceived as an ecological problem. The aim of this study was to determine the prevalence of broad...