189 documents found, page 1 of 19
Bioactive peptides from milk proteins with antioxidant, anti-inflammatory, and ...
Borges, Thaís; Coelho, Pedro; Prudêncio, Cristina; Gomes, Ana; Gomes, Paula; Ferraz, Ricardo; Coelho, Pedro; Prudêncio, Cristina; Ferraz, RicardoPeptides from protein ingredients exhibit key biological activities, including antimicrobial, antihypertensive, antioxidant, anti-inflammatory, analgesic, and immunomodulatory effects. Aligning with the One Health approach, there is growing investment in promoting pet health and well-being. As a result, sustainable functional ingredients are increasingly essential for pet food development. In this work, peptide...
Betulinic acid and obesity-related disorders
Azevedo, Lara; Ferraz, Ricardo; Vieira, Mónica; Prudêncio, Cristina; Fernandes, Sílvia; Ferraz, Ricardo; Almeida Vieira, Mónica AndreiaThe obesity epidemic is not just a health issue, it is increasingly driving a shift in the prevalence of chronic diseases, affecting 890 million adults and straining healthcare systems worldwide. Conditions such as type 2 diabetes mellitus, cardiovascular diseases, non-alcoholic fatty liver disease, and various cancer types are closely tied to this growing crisis. Betulinic acid has anti-inflammatory, antioxida...
Exploring treatment strategies for paroxysmal nocturnal hemoglobinuria: an over...
Peixoto, Vanda; Prudêncio, Cristina; Vieira, MónicaParoxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired disease in which blood cells lack anchored proteins that regulate the complement system. The erythrocytes are then destroyed because of uncontrolled complement activity, leading to intravascular hemolysis (IVH) and a high risk of thrombosis outcome. A huge alteration in the treatment of the disease was the development of terminal complement inhibitor...
From the gut to the brain: Is microbiota a new paradigm in Parkinson’s disease ...
Vilela, Cristiana; Araújo, Bruna; Guedes, Carla; Silva, Rita Caridade; Macedo, Joana Martins; Teixeira, Catarina; Gomes, Eduardo; Prudêncio, CristinaParkinson’s disease (PD) is recognized as the second most prevalent primary chronic neurodegenerative disorder of the central nervous system. Clinically, PD is characterized as a movement disorder, exhibiting an incidence and mortality rate that is increasing faster than any other neurological condition. In recent years, there has been a growing interest concerning the role of the gut microbiota in the etiology...
Evaluation of the impact of two C5 genetic variants on C5-eculizumab complex st...
Peixoto, Vanda; Prudêncio, Cristina; Vieira, Mónica; Sousa, Sérgio F.Complement C5 is the target of the monoclonal antibody eculizumab, used in complement dysregulating disorders, like the rare disease Paroxysmal Nocturnal Hemoglobinuria (PNH). PNH is an acquired hematopoietic stem cell condition characterized by aberrant destruction of erythrocytes, chronic hemolytic anemia, and thromboembolism propensity. C5 is a protein component of the complement system which is part of the ...
Repurposing antiplasmodial leads for cancer: Exploring the antiproliferative ef...
Fonte, Mélanie; Rôla, Catarina; Santana, Sofia; Ferraz, Ricardo; Prudêncio, Miguel; Almeida, Joana; Ferraz, Ricardo; Prudêncio, CristinaDrug repurposing and rescuing have been widely explored as cost-effective approaches to expand the portfolio of chemotherapeutic agents. Based on the reported antitumor properties of both trans-cinnamic acids and quinacrine, an antimalarial aminoacridine, we explored the antiproliferative properties of two series of N-cinnamoyl-aminoacridines recently identified as multi-stage antiplasmodial leads. The compound...
Development of a stable melanoma dual reporter cell line expressing Luciferase ...
Aguiar, Gonçalo; Torres, Sílvia; Prudêncio, Cristina; Soares, Raquel; Coelho, Pedro; Prudêncio, Cristina; Coelho, PedroMelanoma is the most aggressive and lethal form of skin cancer, with a high risk of metastatic spread. Obesity is recognized as a risk factor for various types of cancer. However, regarding melanoma, this association remains controversial. Obesity might act as a double-edged sword in melanoma, promoting primary tumour growth but at the same time limiting metastatic spread - the "obesity paradox”. Herein, we aim...
Potential probiotic and functional properties of Brettanomyces strains isolated...
Areal-Hermida, Lara; Coelho, Pedro; Pichardo-Gallardo, Ángeles; Prudêncio, Cristina; Sieiro, CarmenKombucha, a beverage traditionally obtained through the fermentation of tea, is believed to have beneficial health properties. Therefore, characterizing the microorganisms responsible for this fermentation is essential to demonstrate its potential health benefits and to identify candidates for new probiotics. In this study, four probiotic yeast strains isolated from kombucha tea were identified, by the PCR-RFLP...
Noradrenergic pathways involved in micturition in an animal model of hydrocepha...
Louçano, Marta; Coelho, Ana; Chambel, Sílvia Sousa; Prudêncio, Cristina; Cruz, Célia Duarte; Tavares, IsauraHydrocephalus is characterized by enlargement of the cerebral ventricles, accompanied by distortion of the periventricular tissue. Patients with hydrocephalus usually experience urinary impairments. Although the underlying etiology is not fully described, the effects of hydrocephalus in the neuronal network responsible for the control of urination, which involves periventricular areas, including the periaqueduc...
Affinity coefficient for clustering autoregressive moving average models
Nascimento, Ana Paula; Oliveira, Alexandra; Faria, Brígida Mónica; Pimenta, Rui; Vieira, Mónica; Prudêncio, Cristina; Nicolau, Helena BacelarIn various fields, such as economics, finance, bioinformatics, geology, and medicine, namely, in the cases of electroencephalogram, electrocardiogram, and biotechnology, cluster analysis of time series is necessary. The first step in cluster applications is to establish a similarity/dissimilarity coefficient between time series. This article introduces an extension of the affinity coefficient for the autoregres...