2 documents found, page 1 of 1
Chalcone Derivatives with Potential Antimitotic Activity
Silva, Patrícia M. A.; Alves , Eduarda; Cruz , Lara; Santos , Rita; Pereira , Daniela; Assunção, Henrique; Cidade , Honorina; Bousbaa , HassanBackground: Cancer remains one of the leading causes of mortality worldwide, with incidence rates rising in recent years [1]. Among various therapeutic strategies, microtubule-targeting agents have demonstrated significant efficacy in cancer treatment. However, their clinical application is often limited by high toxicity and tumor resistance [2]. Therefore, the discovery of novel small molecules with antitumor ...
Assessment of the Antitumor Potential of Flavonoid-Amino Acid Conjugates
Barbosa , Flávia; Cunha , Andrea; Pinto , Cláudia; Bousbaa , Hassan; Cidade , Honorina; Silva , Patrícia M. A.; Tiritan , Maria ElizabethBackground: Cancer is a complex disease characterized by multiple alterations that promote uncontrolled cell proliferation and resistance to cell death. Multidrug resistance to conventional chemotherapy often results in treatment failure, highlighting the need for alternative therapeutic strategies [1]. In this context, natural products and their derivatives have attracted significant interest for their potenti...