3 documents found, page 1 of 1
Co-expression network of neural-differentiation genes shows specific pattern in...
Maschietto, Mariana; Tahira, Ana C.; Puga, Renato; Lima, Leandro; Mariani, Daniel; Paulsen, Bruna da Silveira; Belmonte-de-Abreu, PauloBackground: Schizophrenia is a neurodevelopmental disorder with genetic and environmental factors contributing to its pathogenesis, although the mechanism is unknown due to the difficulties in accessing diseased tissue during human neurodevelopment. The aim of this study was to find neuronal differentiation genes disrupted in schizophrenia and to evaluate those genes in post-mortem brain tissues from schizophre...
Gene expression of peripheral blood lymphocytes may discriminate patients with ...
Palha, Joana Almeida; Maschietto, Mariana; Silva, Aderbal R.; Puga, Renato; Lima, Leandro; Pereira, Carlos B.; Nakano, Eduardo Y.; Mello, BarbaraTo identify a classifier in schizophrenia, blood gene expression profiling was applied to patients with schizophrenia under different treatments and to controls. Expression of six genes discriminated patients with sensitivity of 89.3% and specificity of 90%, supporting the use of peripheral blood as biological material for diagnosis in schizophrenia.
Transcriptome signature of the adult mouse choroid plexus
Marques, Fernanda Cristina Gomes de Sousa; Sousa, João Carlos; Coppola, Giovanni; Gao, Fuying; Puga, Renato; Brentani, Helena; Geschwind, Daniel H.Background: Although the gene expression profile of several tissues in humans and in rodent animal models has been explored, analysis of the complete choroid plexus (CP) transcriptome is still lacking. A better characterization of the CP transcriptome can provide key insights into its functions as one of the barriers that separate the brain from the periphery and in the production of cerebrospinal fluid. Method...