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Health-related quality of life at 5 years of age for children born very preterm...

Kim, SW; Tian, X; Andronis, L; Maier, RF; Varendi, H; Seppänen, A-V; Siljehav, V; Draper, ES; Zeitlin, J; Petrou, S; Seppänen, AV; El Rafei, R

Background: This study aimed to investigate the health-related quality of life (HRQoL) at 5 years of age of European children born very preterm across multi-dimensional outcomes by presence and severity of congenital anomalies. Methods: The study used data from a European cohort of children born very preterm (<32 weeks of gestation) and followed up to 5 years of age (N = 3493). Multilevel Ordinary Least Squares...


Prediction of movement difficulties at 5 years from parent report at 2 years in...

Costa, R; Aubert, AM; Seppänen, AV; Ådén, U; Sarrechia, I; Zemlin, M; Cuttini, M; Männamaa, M; Pierrat, V; van Heijst, A; Barros, H; Zeitlin, J

AimTo assess the predictive validity of parent-reported gross motor impairment (GMI) at age 2 years to detect significant movement difficulties at age 5 years in children born extremely preterm. MethodData were from 556 children (270 males, 286 females) born at less than 28 weeks' gestation in 2011 to 2012 in 10 European countries. Parent report of moderate/severe GMI was defined as walking unsteadily or unable...


Risk factors for cerebral palsy and movement difficulties in 5-year-old childre...

Aubert, AM; Costa, R; Johnson, S; Aden, U; Cuttini, M; Koopman-Esseboom, C; Lebeer, J; Varendi, H; Zemlin, M; Pierrat, V; Zeitlin, J

BackgroundMotor impairment is common after extremely preterm (EPT, <28 weeks' gestational age (GA)) birth, with cerebral palsy (CP) affecting about 10% of children and non-CP movement difficulties (MD) up to 50%. This study investigated the sociodemographic, perinatal and neonatal risk factors for CP and non-CP MD.MethodsData come from a European population-based cohort of children born EPT in 2011-2012 in 11 c...


Never-breastfed children face a higher risk of suboptimal cognition at 2 years ...

Rodrigues, C; Zeitlin, J; Zemlin, M; Wilson, E; Pedersen, P; Barros, H

In a cohort of children born very preterm (VPT), we investigated the association between breast milk feeding (BMF) initiation and its duration on cognitive development at 2 years of corrected age. Data were obtained from the Effective Perinatal Intensive Care in Europe population-based prospective cohort of children born <32 weeks of gestation, in 11 European countries, in 2011–2012. The study sample included 4...


Motor-related health care for 5-year-old children born extremely preterm with m...

Costa, R; Aubert, AM; Seppänen, A-V; Ådén, U; Sarrechia, L; Zemlin, M; Cuttini, M; Männamaa, M; Pierrat, V; van Heijst, A; Barros, H; Johnson, S

Aim: To (1) determine the proportion of 5-year-old children born extremely preterm (EPT) with movement difficulties including cerebral palsy (CP) and the proportion of these children receiving motor-related health care (MRHC), and (2) describe factors associated with receiving MRHC. Method: Children born before 28 weeks’ gestation in 2011 to 2012 in 11 European countries were assessed with the Movement Assessme...


Movement Difficulties at Age Five Among Extremely Preterm Infants

Aubert, AM; Costa, R; Ådén, U; Cuttini, M; Männamaa, M; Pierrat, V; Sarrechia, I; van Heijst, AF; Zemlin, M; Johnson, S; Zeitlin, J

BACKGROUND AND OBJECTIVES: Children born extremely preterm (EPT), <28 weeks' gestational age, face higher risks of movement difficulties than their term-born peers. Studies report varying prevalence estimates and prognostic factors identifying children who could benefit from early intervention are inconsistent. This study investigated the prevalence of movement difficulties in children born EPT and associated r...


Association between postnatal growth and neurodevelopmental impairment by sex a...

El Rafei, R; Jarreau, PH; Norman, M; Maier, RF; Barros, H; Van Reempts, P; Pedersen, P; Cuttini, M; Costa, R; Zemlin, M; Draper, ES; Zeitlin, J

Background & aims: Extra-uterine growth restriction (EUGR) is common among very preterm (VPT) infants and has been associated with impaired neurodevelopment. Some research suggests that adverse effects of EUGR may be more severe in boys. We investigated EUGR and neurodevelopment at 2 years of corrected age (CA) by sex in a VPT birth cohort. Methods: Data come from a population-based cohort of children born <32 ...


Neonatal Morbidity and Mortality in Advanced Aged Mothers-Maternal Age Is Not a...

Nourkami-Tutdibi, N; Tutdibi, E; Faas, T; Wagenpfeil, G; Draper, ES; Johnson, S; Cuttini, M; Rafei, RE; Seppänen, AV; Mazela, J; Maier, RF; Nuytten, A

Background: As childbearing is postponed in developed countries, maternal age (MA) has increased over decades with an increasing number of pregnancies between age 35–39 and beyond. The aim of the study was to determine the influence of advanced (AMA) and very advanced maternal age (vAMA) on morbidity and mortality of very preterm (VPT) infants. Methods: This was a population-based cohort study including infants...


Postnatal Corticosteroids Policy for Very Preterm Infants and Bronchopulmonary ...

Nuytten, A; Behal, H; Duhamel, A; Jarreau, PH; Torchin, H; Milligan, D; Maier, RF; Zemlin, M; Zeitlin, J; Truffert, P; EPICE Research Group

Introduction: Postnatal corticosteroids (PNC) are effective for reducing bronchopulmonary dysplasia (BPD) in very preterm neonates but are associated with adverse effects including an increased risk of cerebral palsy. PNC use in Europe is heterogeneous across regions. This study aimed to assess whether European neonatal intensive care units (NICUs) with a low use of PNC or an explicit policy to reduce PNC use h...


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