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Neuromelanin magnetic resonance imaging of the Substantia Nigra in LRRK2-relate...

Guedes, Leonor Correia; Reimão, Sofia; Paulino, Patrícia; Nunes, Rita G.; Bouça-Machado, Raquel; Abreu, Daisy; Gonçalves, Nilza; Soares, Tiago

Date: 2017   |   Origin: Egas Moniz - Cooperativa de Ensino Superior, CRL
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Neuromelanin magnetic resonance imaging of the substantia nigra in LRRK2-relate...

Correia Guedes, Leonor; Reimão, Sofia; Paulino, Patrícia; Nunes, Rita G.; Bouça-Machado, Raquel; Abreu, Daisy; Gonçalves, Nilza; Soares, Tiago

Specific T-weighted MRI sequences are able to detect SN neuromelanin (NM) signal changes and accurately discriminate Parkinson’s disease (PD) patients from controls. The study of NM-MRI in PD patients carrying a LRRK2 gene mutation (LRRK2-PD) could contribute to further uncover LRRK2-associated phenotype. Albeit considered to largely overlap idiopathic PD (iPD), differences have been described. Furthermore, the...

Date: 2017   |   Origin: Repositório da Universidade de Lisboa
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