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Biological activity of neosergeolide and isobrucein B (and two semi-synthetic d...

Silva, Ellen Cristina Costa; Coelho Cavalcanti, Bruno; Amorim, Rodrigo C.N.; Lucena, Jorcilene F.; Quadros, Dulcimar S.; Tadei, Wanderli Pedro

In the present study, in vitro techniques were used to investigate a range of biological activities of known natural quassinoids isobrucein B (1) and neosergeolide (2), known semi-synthetic derivative 1,12-diacetylisobrucein B (3), and a new semi-synthetic derivative, 12-acetylneosergeolide (4). These compounds were evaluated for general toxicity toward the brine shrimp species Artemia franciscana, cytotoxicity...

Date: 2020   |   Origin: Oasisbr
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