2 documents found, page 1 of 1
Stage-independent biomarkers for Alzheimer’s disease from the living retina: an...
Ferreira, Hugo; Serranho, Pedro; Guimarães, Pedro; Trindade, Rita; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; Castelo-Branco, MiguelThe early diagnosis of neurodegenerative disorders is still an open issue despite the many efforts to address this problem. In particular, Alzheimer’s disease (AD) remains undiagnosed for over a decade before the first symptoms. Optical coherence tomography (OCT) is now common and widely available and has been used to image the retina of AD patients and healthy controls to search for biomarkers of neurodegenera...
Tau deletion prevents stress-induced dendritic atrophy in prefrontal cortex: ro...
Lopes, Sofia Oliveira; Teplytska, Larysa; Silva, João Luís Vaz Lima da; Dioli, Chrysoula; Trindade, Rita; Morais, Mónica; Webhofer, ChristianTau protein in dendrites and synapses has been recently implicated in synaptic degeneration and neuronal malfunction. Chronic stress, awell-known inducer of neuronal/synaptic atrophy, triggers hyperphosphorylation of Tau protein and cognitive deficits. However, the cause–effect relationship between these events remains to be established. To test the involvement of Tau in stress-induced impairments of cognition,...