27 documents found, page 1 of 3
3-Bromopyruvate boosts the effect of chemotherapy in acute myeloid leukemia by ...
Vieira, Joana Pereira; Preto, Ana; Granja, Sara; Queirós, Odília; Celeiro, Sónia Pires; Ko, Young Hee; Casal, Margarida; Matos, Catarina BarbosaAcute myeloid leukemia (AML) comprises a diverse group of blood cancers with varying genetic, phenotypic, and clinical traits, making development of targeted therapy challenging. Metabolic reprogramming in AML has been described as relevant for chemotherapy effectiveness. 3-Bromopyruvate (3-BP) is an anticancer agent that undermines energy metabolism of cancer cells. However, the effect of 3-BP in hematologic m...
3-Bromopyruvate boosts the effect of chemotherapy in acute myeloid leukemia by ...
Pereira-Vieira, Joana; Granja, Sara Costa; Celeiro, Sónia Pires; Barbosa-Matos, Catarina; Preto, Ana; Queirós, Odília; Ko, Young Hee; Casal, MargaridaAcute myeloid leukemia (AML) comprises a diverse group of blood cancers with varying genetic, phenotypic, and clinical traits, making development of targeted therapy challenging. Metabolic reprogramming in AML has been described as relevant for chemotherapy effectiveness. 3-Bromopyruvate (3-BP) is an anticancer agent that undermines energy metabolism of cancer cells. However, the effect of 3-BP in hematologic m...
Evaluation of antitumor activity of xanthones conjugated with amino acids
Barbosa, Flávia; Araújo, Joana; F. Gonçalves , Virgínia M.; Palmeira, Andreia; Cunha, Andrea; A. Silva, Patrícia M.; Fernandes, Carla; Pinto, MadalenaBackground: Cancer is a complex disease characterized by several alterations that confer on the cells, the capacity to proliferate uncontrollably and to resist cellular death. Multiresistance to conventional chemotherapy drugs is often the cause of treatment failure; thus, the search for natural products or their derivatives with therapeutic action is essential. Chiral derivatives of xanthones (CDXs) have ...
Glucose metabolism as a potential therapeutic target in Cytarabine-resistant ac...
Pereira-Vieira, Joana; Weber, Daniela D.; Silva, Sâmia; Barbosa-Matos, Catarina; Granja, Sara; Reis, Rui Manuel; Queirós, Odília; Ko, Young H.Altered glycolytic metabolism has been associated with chemoresistance in acute myeloid leukemia (AML). However, there are still aspects that need clarification, as well as how to explore these metabolic alterations in therapy. In the present study, we aimed to elucidate the role of glucose metabolism in the acquired resistance of AML cells to cytarabine (Ara-C) and to explore it as a therapeutic target. Resist...
Glucose metabolism as a potential therapeutic target in cytarabine-resistant ac...
Pereira-Vieira, Joana; Weber, Daniela D.; Silva, Sâmia; Barbosa-Matos, Catarina; Granja, Sara Costa; Reis, R. M.; Queirós, Odília; Ko, Young H.Altered glycolytic metabolism has been associated with chemoresistance in acute myeloid leukemia (AML). However, there are still aspects that need clarification, as well as how to explore these metabolic alterations in therapy. In the present study, we aimed to elucidate the role of glucose metabolism in the acquired resistance of AML cells to cytarabine (Ara-C) and to explore it as a therapeutic target. Resist...
Extracellular matrix collagen I differentially regulates the metabolic plastici...
Tavares-Valente, Diana; Cannone, Stefania; Greco, Maria Raffaella; Carvalho, Tiago Miguel Amaral; Baltazar, Fátima; Queirós, Odília; Agrimi, GennaroPancreatic ductal adenocarcinoma (PDAC) has a 5-year survival rate of less than 10 percent largely due to the intense fibrotic desmoplastic reaction, characterized by high levels of extracellular matrix (ECM) collagen I that constitutes a niche for a subset of cancer cells, the cancer stem cells (CSCs). Cancer cells undergo a complex metabolic adaptation characterized by changes in metabolic pathways and biosyn...
Unravelling the Warburg effect: glycolytic inhibitors as promising agents in ca...
Cunha, Andrea; Silva, Patrícia; Rocha, Ana Catarina; Queirós, OdíliaThe study of metabolic changes in cancer cells and their influence on tumor progression is still a challenge in oncobiology. Cancer cells are characterized by their high rates of glycolysis, even in the presence of oxygen, a phenomenon described as the Warburg effect. The increased glycolytic flux induces extracellular space acidification and boosts the more aggressive characteristics of cancer cells. Since mon...
Special Issue “Novel Developments in the Bioproduction of Biochemicals and Biom...
Almeida, Catarina Dias de; Queirós, OdíliaEditorial
Disruption of pH dynamics suppresses proliferation and potentiates doxorubicin ...
Tavares-Valente, Diana; Sousa, Bárbara; Schmitt, Fernando; Baltazar, Fátima; Queirós, OdíliaThe reverse pH gradient is a major feature associated with cancer cell reprogrammed metabolism. This phenotype is supported by increased activity of pH regulators like ATPases, carbonic anhydrases (CAs), monocarboxylate transporters (MCTs) and sodium–proton exchangers (NHEs) that induce an acidic tumor microenvironment, responsible for the cancer acid-resistant phenotype. In this work, we analyzed the expressio...
Xylose metabolism in bacteria : opportunities and challenges towards efficient ...
Domingues, Rafael; Bondar, Maryna; Palolo, Inês; Queirós, Odília; Almeida, Catarina Dias de; Cesário, M. TeresaIn a sustainable society based on circular economy, the use of waste lignocellulosic biomass (LB) as feedstock for biorefineries is a promising solution, since LB is the world’s most abundant renewable and non-edible raw material. LB is available as a by-product from agricultural and forestry processes, and its main components are cellulose, hemicellulose, and lignin. Following suitable physical, enzymatic, and...