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MDMA and tramadol or tapentadol co-administration causes serotonin-independent ...
Faria, Juliana; Barbosa, Joana; Queirós , Odília; Dinis-Oliveira , Ricardo JorgeThe simultaneous consumption and misuse of different drugs, including 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) and opioids, raise concerns about fatal intoxications, as a result of increased serotonin levels. However, research on the simultaneous consumption of MDMA and opioids is limited. This study aimed to evaluate the toxic effect of the simultaneous exposure of the undifferentiated human SH-SY5Y...
Assessment of the Antitumor Potential of Flavonoid-Amino Acid Conjugates
Barbosa , Flávia; Cunha , Andrea; Pinto , Cláudia; Bousbaa , Hassan; Cidade , Honorina; Silva , Patrícia M. A.; Tiritan , Maria ElizabethBackground: Cancer is a complex disease characterized by multiple alterations that promote uncontrolled cell proliferation and resistance to cell death. Multidrug resistance to conventional chemotherapy often results in treatment failure, highlighting the need for alternative therapeutic strategies [1]. In this context, natural products and their derivatives have attracted significant interest for their potenti...