5 documents found, page 1 of 1
Disrupting SARS-CoV-2 Spike Protein Activity: A Virtual Screening and Binding A...
Queirós-Reis, L; Alvites, R; Maurício, AC; Brancale, A; Bassetto, M; Mesquita, JRSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a respiratory virus that emerged in late 2019 and rapidly spread worldwide, causing the COVID-19 pandemic. The spike glycoprotein (S protein) plays a crucial role in viral target recognition and entry by interacting with angiotensin, converting enzyme 2 (ACE2), the functional receptor for the virus, via its receptor binding domain (RBD). The RBD av...
Genomic characterization and cross-species transmission potential of hedgehog c...
Cruz, AVS; Santos-Silva, S; Queirós-Reis, L; Rodrigues, C; Soeiro, V; Tarlinton, RE; Soeiro, VIn the 21st century, three betacoronaviruses (SARS-CoV, MERS-CoV and SARS-CoV-2) have emerged in humans worldwide as a result of animal spillover, causing severe respiratory infections and resulting in more than seven million deaths. In 2013, a novel Betacoronavirus closely related to MERS-CoV (Betacoronavirus cameli) was discovered in European hedgehogs (Erinaceus europaeus), raising questions on the possibili...
Exploring the Fatty Acid Binding Pocket in the SARS-CoV-2 Spike Protein - Confi...
Queirós-Reis, L; Mesquita, JR; Brancale, A; Bassetto, MSevere Acute Respiratory syndrome 2 (SARS-CoV-2) is a respiratory virus responsible for coronavirus disease 19 (COVID-19) and the still ongoing and unprecedented global pandemic. The key viral protein for cell infection is the spike glycoprotein, a surface-exposed fusion protein that both recognizes and mediates entry into host cells. Within the spike glycoprotein, a fatty acid binding pocket (FABP) was confirm...
De Novo Assembly of the Dirofilaria immitis Genome by Long-Read Nanopore-Based ...
Gomes-de-Sá, S; Barradas, P; Queirós-Reis, L; Matas, IM; Amorim, I; Cardoso, L; Muñoz-Mérida, A; Mesquita, JRDirofilaria immitis is a zoonotic parasitic nematode that infects domestic and wild canids, among its vertebrate hosts. The genetic analysis of D. immitis nowadays transcends the need for genetic taxonomy of nematodes, such as the study of resistance to macrocyclic lactone. We expanded the use of long-read nanopore-based sequencing technology on nematodes by performing genomic de novo assembly of a D. immitis s...
SARS-CoV-2 Virus-Host Interaction: Currently Available Structures and Implicati...
Queirós-Reis, L; Gomes da Silva, P; Gonçalves, J; Brancale, A; Bassetto, M; Mesquita, JRCoronavirus disease 19, or COVID-19, is an infection associated with an unprecedented worldwide pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which has led to more than 215 million infected people and more than 4.5 million deaths worldwide. SARS-CoV-2 cell infection is initiated by a densely glycosylated spike (S) protein, a fusion protein, binding human angiotensin conver...