157 documents found, page 1 of 16
Paving the way for a non‐antibiotic and microbiota friendly therapy for Helicob...
Seabra, CL; Pinho, AS; Nunes, C; Amorim, I; Pedro, N; Henriques, P; Monteiro, C; Gomes, J; Machado, C; Gartner, F; Pereira, L; Reis, S; Reis, CABackground: The World Health Organization has identified Helicobacter pylori, a Gram-negative bacterium responsible for several gastric disorders, as one of the pathogenic bacteria that requires newer non-antibiotic approaches for its management. We previously demonstrated that nanostructured lipid carriers (NLC) loaded with docosahexaenoic acid (DHA-NLC)have excellent in vitro performance against H. pylori. Ma...
Bragg Gratings in ZEONEX Microstructured Polymer Optical Fiber With 266-nm Nd:Y...
Pereira, L; Marques, C; Min, R; Woyessa, G; Bang, O; Humberto Varum; Antunes, PFDWe present the first fiber Bragg gratings (FBGs) inscription in ZEONEX-480R microstructured polymer optical fiber (POF) by employing the fourth harmonic (266 nm) of a Nd:YAG laser system. The gratings were produced in the L-band region by the phase mask method, in 270-mu m diameter POF samples connectorized with ferrule connectors (FCs). The results of three produced gratings are reported, showing good stabilit...
Interrogation Method with Temperature Compensation Using Ultra-Short Fiber Brag...
Pereira, L; Min, R; Woyessa, G; Bang, O; Marques, C; Humberto Varum; Antunes, PThe use of simpler and less bulky equipment, with a reliable performance and at relative low cost is increasingly important when assembling sensing configurations for a wide variety of applications. Based on this concept, this paper proposes a simple, efficient and relative low-cost fiber Bragg grating (FBG) interrogation solution using ultra-short FBGs (USFBGs) as edge filters. USFBGs with different lengths an...
Serum amyloid A proteins reduce bone mass during mycobacterial infections
Gomes, AC; Sousa, DM; Oliveira, TC; Fonseca, O; Pinto, RJ; Silvério, D; Fernandes, AI; Moreira, AC; Silva, T; Teles, MJ; Pereira, L; Saraiva, MIntroductionOsteopenia has been associated to several inflammatory conditions, including mycobacterial infections. How mycobacteria cause bone loss remains elusive, but direct bone infection may not be required. MethodsGenetically engineered mice and morphometric, transcriptomic, and functional analyses were used. Additionally, inflammatory mediators and bone turnover markers were measured in the serum of healt...
InfectionCMA: A Cell MicroArray Approach for Efficient Biomarker Screening in I...
Magalhães, AC; Ricardo, S; Moreira, AC; Nunes, M; Tavares, M; Pinto, RJ; Gomes, MS; Pereira, LThe recently emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has forced the scientific community to acquire knowledge in real-time, when total lockdowns and the interruption of flights severely limited access to reagents as the global pandemic became established. This unique reality made researchers aware of the importance of designing efficient in vitro set-ups to evaluate infectious kinet...
Nationwide Access to Endovascular Treatment for Acute Ischemic Stroke in Portugal
Carvalho Dias, M; Soares dos Reis, R; Santos, JV; Paiva Nunes, A; Ferreira, P; Maia, B; Fragata, I; Reis, J; Ramos Lopes, J; Cruz, L; Santo, GIntroduction: Since the publication of endovascular treatment trials and European Stroke Guidelines, Portugal has re-organized stroke healthcare. The nine centers performing endovascular treatment are not equally distributed within the country, which may lead to differential access to endovascular treatment. Our main aim was to perform a descriptive analysis of the main treatment metrics regarding endovascular ...
Minimally invasive surgery for spinal fractures due to multiple myeloma
Alves, OL; Reinas, R; Kitumba, D; Pereira, LBackground: Multiple myeloma (MM) presents with spinal lesions in 60% of cases. The combination of osteolytic lesions with multifactorial osteopenia raises specific surgical treatment challenges. Minimally invasive spine surgery (MISS) could be a potential option for MM spinal lesions treatment. Objective: The objective of this study is to evaluate MISS techniques to treat patients presenting with spine fractur...
Inhibition of CXCR2 Plays a Pivotal Role in Re-Sensitizing Ovarian Cancer to Ci...
Henriques, TB; Santos, DZ; Guimarães, IDS; Tessarollo, NG; Lyra-Junior, PCM; Mesquita, P; Pádua, D; Amaral, AL; Cavadas, B; Pereira, L; Silva, IVcDNA microarray data conducted by our group revealed overexpression of CXCL2 and CXCL8 in ovarian cancer (OC) microenvironment. Herein, we have proven that the chemokine receptor, CXCR2, is a pivotal molecule in re-sensitizing OC to cisplatin, and its inhibition decreases cell proliferation, viability, tumor size in cisplatinresistant cells, as well as reversed the overexpression of mesenchymal epithelium trans...
Iron Related Biomarkers Predict Disease Severity in a Cohort of Portuguese Adul...
Moreira, AC; Teles, MJ; Silva, T; Bento, CM; Alves, IS; Pereira, L; Guimarães, JT; Porto, G; Oliveira, P; Gomes, MSLarge variability in COVID-19 clinical progression urges the need to find the most relevant biomarkers to predict patients’ outcomes. We evaluated iron metabolism and immune response in 303 patients admitted to the main hospital of the northern region of Portugal with variable clinical pictures, from September to November 2020. One hundred and twenty-seven tested positive for SARS-CoV-2 and 176 tested negative....
Field and Molecular Epidemiology: How Viral Sequencing Changed Transmission Inf...
Pedro, N; Fernandes, V; Cavadas, B; Guimarães, JT; Barros, H; Tavares, M; Pereira, LField epidemiology and viral sequencing provide a comprehensive characterization of transmission chains and allow a better identification of superspreading events. However, very few examples have been presented to date during the COVID-19 pandemic. We studied the first COVID-19 cluster detected in Portugal (59 individuals involved amongst extended family and work environments), following the return of four rela...