4 documents found, page 1 of 1
Unexpected Therapeutic Effects of Common Drugs: Lessons from 15 Years of Drug R...
Gonçalves, Jorge Manuel Moreira; Quintas, Clara; Silva, Dany; Queiroz, Glória; Fresco, PaulaDrug repurposing (DR) is one of the expressions that has been used to translate the process of discovering new therapeutic uses for drugs already approved for other clinical indications. The concept was presented 15 years ago. Initially, the intention was to shorten the pharmaceutical research and development (R&D) process and thereby reduce the costs and risks for the pharmaceutical industry to bring new m...
Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindol...
Soares, Joana; Raimundo, Liliana; Pereira, Nuno A. L.; Monteiro, Ângelo; Gomes, Sara; Bessa, Cláudia; Pereira, Clara; Queiroz, Glória; Bisio, AlessandraRestoration of the p53 pathway, namely by reactivation of mutant (mut) p53, represents a valuable anticancer strategy. Herein, we report the identification of the enantiopure tryptophanol-derived oxazoloisoindolinone SLMP53-1 as a novel reactivator of wild-type (wt) and mut p53, using a yeast-based screening strategy. SLMP53-1 has a p53-dependent anti-proliferative activity in human wt and mut p53R280K-expressi...
Ethnopharmacological notes about ancient uses of medicinal plants in Trás-os-Mo...
Neves, José Manuel Gomes da Silva; Matos, Carla; Moutinho, Carla; Queiroz, Glória; Gomes, Lígia RebeloAim of the study In order to preserve the ancestral knowledge, an ethnopharmacological study has been carried out in two councils belonging to Trás-os-Montes region a small area located in the northern of Portugal. In that area, medicinal plants, most of the species wild, are still in use among farmers, shepherds and other people who live far from villages and built-up areas. Materials and methods Among the 46 ...
Ethnopharmacological notes about ancient uses of medicinal plants in Trás-os-Mo...
Neves, J. M.; Matos, Carla Manuela; Moutinho, C.; Queiroz, Glória; Gomes, Lígia RebeloAim of the study In order to preserve the ancestral knowledge, an ethnopharmacological study has been carried out in two councils belonging to Trás-os-Montes region a small area located in the northern of Portugal. In that area, medicinal plants, most of the species wild, are still in use among farmers, shepherds and other people who live far from villages and built-up areas. Materials and methods Among the 46 ...