10 documents found, page 1 of 1
Image-guided nanodelivery of Pt(IV) prodrugs to GRP-receptor positive tumors
Silva, Francisco; Mendes, Carolina; D'Onofrio, Alice; Campello, Maria Paula Cabral; Marques, Fernanda; Pinheiro, Teresa; Gonçalves, KyleOver the last decades, gold nanoparticles (AuNPs) have proven to be remarkable tools for drug delivery and theranostic applications in cancer treatment. On the other hand, Pt(IV) prodrugs have been employed as an interesting alternative to the more common Pt(II) complexes, such as cisplatin, for cancer chemotherapy. Searching to design an image-guided nanocarrier to deliver selectively Pt(IV) prodrugs to tumors...
Dose rate effects on the selective radiosensitization of prostate cells by GRPR...
Marques, Ana; Belchior, Ana; Silva, Francisco; Marques, Fernanda; Campello, Maria Paula Cabral; Pinheiro, Teresa; Santos, Pedro; Santos, LuisFor a while, gold nanoparticles (AuNPs) have been recognized as potential radiosensitizers in cancer radiation therapy, mainly due to their physical properties, making them appealing for medical applications. Nevertheless, the performance of AuNPs as radiosensitizers still raises important questions that need further investigation. Searching for selective prostate (PCa) radiosensitizing agents, we studied the r...
Aptamer-Functionalized Gold Nanoparticles for Drug Delivery to Gynecological Ca...
Lopes-Nunes, Jessica; Agonia, Ana S.; Rosado, Tiago; Gallardo, Eugenia; Palmeira-de-Oliveira, Rita; Palmeira-de-Oliveira, AnaCervical cancer is one of the most common cancers and is one of the major cause of deaths in women, especially in underdeveloped countries. The patients are usually treated with surgery, radiotherapy, and chemotherapy. However, these treatments can cause several side effects and may lead to infertility. Another concerning gynecologic cancer is endometrial cancer, in which a high number of patients present a poo...
Dual Imaging Gold Nanoplatforms for Targeted Radiotheranostics
Silva, Francisco; Paulo, António; Pallier, Agnès; Même, Sandra; Tóth, Éva; Gano, Lurdes; Marques, Fernanda; Geraldes, Carlos F. G. C.Gold nanoparticles (AuNPs) are interesting for the design of new cancer theranostic tools, mainly due to their biocompatibility, easy molecular vectorization, and good biological half-life. Herein, we report a gold nanoparticle platform as a bimodal imaging probe, capable of coordinating Gd3+ for Magnetic Resonance Imaging (MRI) and 67Ga3+ for Single Photon Emission Computed Tomography (SPECT) imaging. Our AuNP...
In vivo pretargeting based on cysteine-selective antibody modification with IED...
Ferreira, Vera F. C.; Oliveira, Bruno; D'Onofrio, Alice; Farinha, Carlos; Gano, Lurdes; Paulo, António; Bernardes, Gonçalo J. L.; Mendes, FilipaPretargeted imaging has emerged as an effective multistep strategy aiming to improve imaging contrast and reduce patient radiation exposure through decoupling of the radioactivity from the targeting vector. The inverse electron-demand Diels-Alder (IEDDA) reaction between a trans-cyclooctene (TCO)-conjugated antibody and a labeled tetrazine holds great promise for pretargeted imaging applications due to its bioo...
Radiobiological Characterization of 64CuCl₂ as a Simple Tool for Prostate Cance...
Guerreiro, Joana Fernandes; Alves, Vítor; Abrunhosa, Antero José; Paulo, António; Gil, Octávia Monteiro; Mendes, Filipa64CuCl₂ has recently been proposed as a promising agent for prostate cancer (PCa) theranostics, based on preclinical studies in cellular and animal models, and on the increasing number of human studies documenting its use for PCa diagnosis. Nevertheless, the use of 64CuCl₂ raises important radiobiological questions that have yet to be addressed. In this work, using a panel of PCa cell lines in comparison with a...
Molecular imaging agents for detection of β-amyloid plaques in Alzheimer’s disease
Quental, Letícia; Ribeiro Morais, Goreti; Santos, Isabel; Paulo, AntónioThe formation of amyloid structures is a neuropathological feature that characterizes several neurodegenerative disorders, such as Alzheimer´s and Parkinson´s disease. Up to now, the definitive diagnostic of these diseases can only be accomplished by immunostaining of post-mortem brain tissues with dyes such as Thioflavin T and congo red. Aiming at early in vivo diagnosis of Alzheimer´s disease (AD), several am...
Molecular imaging agents for detection of β-amyloid plaques in Alzheimer’s disease
Quental, Letícia; Morais, Goreti Ribeiro; Santos, Isabel; Paulo, AntónioThe formation of amyloid structures is a neuropathological feature that characterizes several neurodegenerative disorders, such as Alzheimer´s and Parkinson´s disease. Up to now, the definitive diagnosis of these diseases can only be accomplished by immunostaining of post mortem brain tissues with dyes such Thioflavin T and congo red. Aiming at early in vivo diagnosis of Alzheimer´s disease (AD), several amyloi...
Synthesis and biological studies of pyrazolyl-diamine Pt(II) complexes containi...
Gama, Sofia; Mendes, Filipa; Esteves, Teresa; Marques, Fernanda; Matos, António; Rino, José; Coimbra, Joana; Ravera, Mauro; Gabano, ElisabettaNew [PtCl(pz*NN)](n+) complexes anchored by pyrazolyl-diamine (pz*NN) ligands incorporating anthracenyl or acridine orange DNA-binding groups have been synthesized so as to obtain compounds that would display synergistic effects between platination and intercalation of DNA. Study of their interaction with supercoiled DNA indicated that the anthracenyl-containing complex L(2) Pt displays a covalent type of bindi...
Tricarbonyl M(I) (M = Re, 99mTc) complexes bearing acridine fluorophores : synt...
Esteves, Teresa; Xavier, Catarina; Gama, Sofia; Mendes, Filipa; Raposinho, Paula D.; Marques, Fernanda; Paulo, António; Pessoa, João Costa; Rino, JoséNew pyrazolyl-diamine ligands with acridine derivatives at the 4-position of the pyrazolyl ring were synthesized and characterized (L1 and L2). Coordination towards the fac-[M(CO)3]+ (M = Re, 99mTc) led to complexes fac-[M(CO)3(κ3-L)] (L = L1: M = Re1, Tc1; L = L2: M = Re2, Tc2). The interaction of the novel pyrazolyl-diamine ligands (L1 and L2) and rhenium(I) complexes (Re1 and Re2) with calf thymus DNA (CT-DN...