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Synthesis of novel methyl 3-(Hetero)arylthieno[3,2-b]pyridine-2-carboxylates an...
Silva, BR; Rebelo, R; Rodrigues, JM; Xavier, CPR; Vasconcelos, MH; Queiroz, MJRPA series of novel functionalized methyl 3-(hetero)arylthieno[3,2-b]pyridine-2-carboxylates 2a–2h were synthesized by C-C Pd-catalyzed Suzuki-Miyaura cross-coupling of methyl 3-bromothie-no[3,2-b]pyridine-2-carboxylate with (hetero)aryl pinacol boranes, trifluoro potassium boronate salts or boronic acids. Their antitumoral potential was evaluated in two triple negative breast cancer (TNBC) cell lines—MDA-MB-231 ...
Date: 2021
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Origin: Repositório Aberto da Universidade do Porto