162 documents found, page 1 of 17
Magnetoliposomes based on magnetic/plasmonic nanoparticles loaded with tricycli...
Rio, Irina S.R.; Rodrigues, Ana Rita O.; Rodrigues, Juliana M.; Queiroz, Maria João R.P.; Calhelha, Ricardo C.; Ferreira, Isabel C.F.R.Liposome-like nanoarchitectures containing manganese ferrite nanoparticles covered or decorated with gold were developed for application in dual cancer therapy, combining chemotherapy and photothermia. The magnetic/plasmonic nanoparticles were characterized using XRD, UV/Visible absorption, HR-TEM, and SQUID, exhibiting superparamagnetic behavior at room temperature. The average size of the gold-decorated nanop...
Synthesis of novel methyl 7-[(Hetero)arylamino]thieno[2,3-b] pyrazine-6-carboxy...
Rodrigues, Juliana M.; Calhelha, Ricardo C.; Nogueira, António José M.; Ferreira, Isabel C.F.R.; Barros, Lillian; Queiroz, Maria João R.P.Several novel methyl 7-[(hetero)arylamino]thieno[2,3-b]pyrazine-6-carboxylates were synthe-sized by Pd-catalyzed C–N Buchwald–Hartwig cross-coupling of either methyl 7-aminothieno[3,2-b] pyrazine-6-carboxylate with (hetero)arylhalides or 7-bromothieno[2,3-b]pyrazine-6-carboxylate with (hetero)arylamines in good-to-excellent yields (50% quantitative yield), using different reaction conditions, namely ligands and...
Application of PEG400 in the one-pot synthesis of 7-[4-alkyl- or (hetero)aryl-1...
Rodrigues, Juliana M.; Calhelha, Ricardo C.; Ferreira, Isabel C.F.R.; Queiroz, Maria João R.P.Several novel 7-[4-alkyl- or (hetero)aryl-1H-1,2,3-triazol-1-yl]thieno[3,2-b]pyridines were prepared in good to high yields, using the environmentally friendly solvent PEG400 in a one-pot procedure from 7-chlorothieno[3,2-b]pyridine to form the corresponding azide via SNAr with NaN3, followed by Cu(I)-catalyzed Azide-Alkyne Cycloaddition (CuAAC) using different types of alkynes. This one-pot reaction in PEG400 ...
Magnetoliposomes containing calcium ferrite nanoparticles for applications in b...
Pereira, Daniela S.M.; Cardoso, Beatriz D.; Rodrigues, Ana Rita O.; Amorim, Carlos O.; Amaral, Vítor S.; Almeida, Bernardo G.; Queiroz, Maria João R.P.Magnetoliposomes containing calcium ferrite (CaFe2O4) nanoparticles were developed and characterized for the first time. CaFe2O4 nanoparticles were covered by a lipid bilayer or entrapped in liposomes forming, respectively, solid or aqueous magnetoliposomes as nanocarriers for new antitumor drugs. The magnetic nanoparticles were characterized by UV/Visible absorption, XRD, HR-TEM, and SQUID, exhibiting sizes of...
Magnetoliposomes as carriers for promising antitumor thieno[3,2-b]pyridin-7-ary...
Rodrigues, Ana Rita O.; Almeida, Bernardo G.; Rodrigues, Juliana M.; Queiroz, Maria João R.P.; Calhelha, Ricardo C.; Ferreira, Isabel C.F.R.; Pires, A.Magnetoliposomes containing superparamagnetic manganese ferrite nanoparticles were tested as nanocarriers for two new promising antitumor drugs, a N-(3-methoxyphenyl)thieno[3,2-b]pyridin-7-amine (1) and a N-(2-methoxy-phenyl)thieno[3,2-b] pyridin-7-amine (2). The fluorescence emission of both compounds was studied in different polar and non-polar media, evidencing a strong intramolecular charge transfer charact...
Chemical characterization, antioxidant, anti-inflammatory and cytotoxic propert...
Sobral, Filipa; Sampaio, Andreia; Falcão, Soraia; Queiroz, Maria João R.P.; Calhelha, Ricardo C.; Vilas-Boas, Miguel; Ferreira, Isabel C.F.R.Bee venom (BV) or apitoxin is a complex mixture of substances with reported biological activity. In the present work, five bee venom samples obtained from Apis mellifera iberiensis from the Northeast Portugal (two different apiaries) were chemically characterized and evaluated for their antioxidant, anti-inflammatory and cytotoxic properties. The LC/DAD/ESI-MS(n) analysis of the samples showed that melittin was...
Wild Roman chamomile extracts and phenolic compounds: enzymatic assays and mole...
Guimarães, Rafaela; Calhelha, Ricardo C.; Froufe, Hugo J.C.; Abreu, Rui M.V.; Carvalho, Ana Maria; Queiroz, Maria João R.P.; Ferreira, Isabel C.F.R.Angiogenesis is a process by which new blood vessels are formed from the pre-existing vasculature, and it is a key process that leads to tumour development. Some studies have recognized phenolic compounds as chemopreventive agents; flavonoids, in particular, seem to suppress the growth of tumor cells modifying the cell cycle. Herein, the antiangiogenic activity of Roman chamomile (Chamaemelum nobile L.) extract...
Contribution of phenolic acids to the anti-inflammatory activity of edible myco...
Taofiq, Oludemi; Calhelha, Ricardo C.; Heleno, Sandrina A.; Barros, Lillian; Martins, Anabela; Santos-Buelga, Celestino; Queiroz, Maria João R.P.Edible mycorrhizal mushrooms are 1ich in several bioactive compounds responsible for their interesting health benefits (1). Polysaccharides, terpenoids and phenolic compounds have been indicated as the most important contributors to the anti-inflanunatory activity of mushroom species (2). In the present study, ethanolic extracts of seven mycorrhizal mushrooms were obtained by maceration and chemically character...
Patente Nacional nº 107646 - Método de obtenção do éster metílico do ácido acet...
Queiroz, Maria João R.P.; Esteves, Ana P.; Martins, Anabela; Heleno, Sandrina A.; Ferreira, Isabel C.F.R.A presente invenção consiste num novo método para a produção do éster metílico do ácido acetobromo Α-D-glucurónico. Com este método, obtém-se um rendimento global de 42%. O processo consiste na produção do intermediário éster Metílico-Β-d-tetra-o-acetilado do ácido glucurónico com um rendimento de 64% e, fazendo reagir este produto com anidrido acético na presença de ácido perclórico, Fósforo vermelho, bromo, e...
A importância dos ácidos fenólicos na atividade anti-inflamatória de cogumelos ...
Taofiq, Oludemi; Calhelha, Ricardo C.; Heleno, Sandrina A.; Barros, Lillian; Martins, Anabela; Santos-Buelga, Celestino; Queiroz, Maria João R.P.Os cogumelos comestíveis são uma fonte rica de moléculas bioativas que lhes conferem importantes atividades biológicas. Moléculas como os Polissacáridos, terpenóides e os compostos fenólicos têm sido descritos como os componentes mais importantes no que respeita á atividade anti-inflamatória dos cogumelos (1). No presente trabalho, os extratos etanólicos de cogumelos comestíveis foram obtidos por maceração e ca...