5 documents found, page 1 of 1
Urinary Cysteinyl Leukotrienes as Biomarkers of Endothelial Activation, Inflamm...
Reina-Couto, M; Santos-Oliveira, M; Pereira-Terra, P; Silva-Pereira, C; Quelhas-Santos, J; Duarte, Á; Martins, S; Serrão, P; Dias, CC; Morato, MCysteinyl leukotrienes (CysLT) are potent vascular leakage-promoting agents but have been scarcely explored in human septic shock (SS). We evaluated CysLT at admission and during hospitalization and their correlation with endothelial dysfunction, inflammation, oxidative stress, the renin–angiotensin–aldosterone system, and cardiac, renal, respiratory, and hepatic parameters in SS patients. Blood and spot-urine ...
Low bone turnover is associated with plain X-ray vascular calcification in pred...
Neto, R; Pereira, L; Magalhães, J; Quelhas-Santos, J; Frazão, JMBackground Vascular calcification (VC) is a common finding in chronic kidney disease (CKD) patients and predicts subsequent cardiovascular morbidity and mortality in this population. Vascular calcification is linked to disordered mineral metabolism and has been associated with bone histomorphometry changes in CKD. However, data on predialysis patients is scarce. Methods A cross-sectional study was conducted on ...
Circulating renalase as predictor of renal and cardiovascular outcomes in pre-d...
Cerqueira, A; Quelhas-Santos, J; Ferreira, I; Sampaio, S; Relvas, M; Marques, N; Dias, CC; Pestana, MChronic kidney disease (CKD) is an independent risk factor for adverse cardiovascular and cerebrovascular events (MACCEs), and mortality since the earlier stages. Therefore, it is critical to identify the link between CKD and cardiovascular risk (CVR) through early and reliable biomarkers. Acknowledging that CKD and CKD progression are associated with increased sympathetic tone, which is implicated in CVR, and ...
Sclerostin and DKK1 circulating levels associate with low bone turnover in pati...
Neto, R; Pereira, L; Magalhães, J; Quelhas-Santos, J; Martins, S; Carvalho, C; Frazão, JMBackground: Disordered mineral and bone metabolism is a common complication of chronic kidney disease (CKD). Bone biopsy remains the gold standard tool for evaluating renal osteodystrophy (ROD), but it is an invasive procedure. Despite a growing interest in the ability of newer bone biomarkers to discriminate between different forms of ROD, data on pre-dialysis patients are scarce. Methods: A cross-sectional st...
Endothelial dysfunction is associated with cerebrovascular events in pre-dialys...
Cerqueira, A; Quelhas-Santos, J; Sampaio, S; Ferreira, I; Relvas, M; Marques, N; Dias, CC; Pestana, MBackground: Patients with chronic kidney disease (CKD) have markedly increased rates of end stage renal disease, major adverse cardiovascular/cerebrovascular events (MACCEs), and mortality. Endothelial dysfunction (ED) is an early marker of atherosclerosis that is emerging as an increasingly important non-traditional cardiovascular risk factor in CKD. There is a lack of clinical studies examining the associatio...