4 documents found, page 1 of 1
Exoproteomic analysis of two MLST clade 2 strains of Clostridioides difficile f...
Pacífico, Dvison de Melo; Costa, Cecília Leite; Moura, Hercules; Barr, John R.; Maia, Guilherme Augusto; Benetti Filho, Vilmar; Moreira, Renato SimõesClostridioides difficile BI/NAP1/ribotype 027 is an epidemic hypervirulent strain found worldwide, including in Latin America. We examined the genomes and exoproteomes of two multilocus sequence type (MLST) clade 2 C. difficile strains considered hypervirulent: ICC‑45 (ribotype SLO231/UK[CE]821), isolated in Brazil, and NAP1/027/ST01 (LIBA5756), isolated during a 2010 outbreak in Costa Rica. C. difficile isolat...
Transforming growth factor β1/SMAD signaling pathway activation protects the in...
Tinoco-Veras, Christianne Maria; Santos, Ana Angélica Q. A.; Stipursky, Joice; Meloni, Marcelo; Araujo, Ana Paula Bérgamo; Foschetti, Danielle AbreuClostridium difficile , the main cause of diarrhea in hospitalized patients, produces toxins A (TcdA) and B (TcdB), which affect intestinal epithelial cell survival, proliferation, and migration and induce an intense inflammatory response. Trans- forming growth factor (TGF- ) is a pleiotropic cytokine affecting enterocyte and immune/inflammatory responses. However, it has been shown that exposure of in- testina...
Emergence of an outbreak-associated clostridium difficile variant with increased...
Quesada-Gómez, Carlos; López-Ureña, Diana; Acuña-Amador, Luis; Villalobos-Zúñiga, Manuel; Du, Tim; Freire, Rosemayre; Guzmán-Verri, CaterinaThe prevalence of Clostridium difficile infections has increased due to the emergence of epidemic variants from diverse genetic lineages. Here we describe the emergence of a novel variant during an outbreak in a Costa Rican hospital that was associated with severe clinical presentations. This C. difficile variant elicited higher white blood cell counts and caused disease in younger patients than did other strai...
Community-acquired diarrhea associated with Clostridium difficile in an HIV-pos...
Costa, Cecíia L.; Quesada-Gómez, Carlos; Carvalho, Cibele B. Mano de; González, Rafael H.; Gifoni, Markus A.; Ribeiro, Ronaldo A.Clostridium difficile is the most important cause of nosocomial diarrhea, mainly associated with antibiotic use and immunodeficiency. Although, an increased incidence of community-acquired C. difficile infection (CA-CDI) has been reported worldwide, this infection has been under-diagnosed in Latin America. This is the first report of a CA-CDI case in Latin America, in an HIV-positive patient with cancer.