32 documents found, page 1 of 4

Correction to: effects of low-intensity training on the brain and muscle in the...

Effects of low-intensity training on the brain and muscle in the congenital mus...

Antidepressants, antimicrobials or both? Gut microbiota dysbiosis in depression...

Objectives The first drug repurposed for the treatment of depression was the tuberculostatic iproniazid. At present, drugs belonging to new classes of antidepressants still have antimicrobial effects. Dysbiosis of gut microbiota was implicated in the development or exacerbation of mental disorders, such as major depressive disorder (MDD). Based on the current interest in the gut-brain axis, the focus of this na...

Food addiction: prevalence, psychopathological correlates and associations with...

Objective: To determine the prevalence of food addiction in a large Brazilian non-clinical sample. Sociodemographic and psychopathological correlates of food addiction as well as associations with quality (QoL) domains were also investigated. Methods: This cross-sectional study obtained data from a Brazilian anonymous web-based research platform (N = 7639; 71.3% females). Participants provided sociodemographic ...

Imipramine reverses depressive-like parameters in pneumococcal meningitis survi...

Pneumococcal meningitis is a severe infectious disease of the central nervous system, associated with acute inflammation and might cause damage to the host, such as deafness, blindness, seizure, and learning deficits. However, infectious diseases can play a significant role in the etiology of neuropsychiatric disturbances. In this context, we evaluated depressive-like parameters; corticosterone and ACTH levels ...

Inhibition of indoleamine 2,3-dioxygenase prevented cognitive impairment in adu...

Streptococcus pneumoniae is a common cause of forms of bacterial meningitis that have a high mortality rate and cause long-term neurologic sequelae. We evaluated the effects of an indoleamine 2,3-dioxygenase (IDO) inhibitor on proinflammatory mediators and memory in Wistar rats subjected to pneumococcal meningitis. The animals were divided into 4 groups: sham, sham treated with IDO inhibitor, meningitis, and me...

Cannabidiol reduces host immune response and prevents cognitive impairments in ...

Pneumococcal meningitis is a life-threatening disease characterized by an acute infection affecting the pia matter, arachnoid and subarachnoid space. The intense inflammatory response is associated with a significant mortality rate and neurologic sequelae, such as, seizures, sensory-motor deficits and impairment of learning and memory. The aim of this study was to evaluate the effects of acute and extended admi...

Neonatal Escherichia coli K1 meningitis causes learning and memory impairments ...

Neonatal Escherichia coli meningitis continues to be an important cause of mortality and morbidity in newborns worldwide. The aim of this study was to investigate the cytokines/chemokines, brain-derived neurotrophic factor (BDNF) levels, blood–brain barrier integrity in neonatal rats following E. coli K1 experimental meningitis infection and subsequent behavioural parameters in adulthood. In the hippocampus, in...

Quetiapine treatment reverses depressive-like behavior and reduces DNA methyltr...

Stress in early life has been appointed as an important phenomenon in the onset of depression and poor response to treatment with classical antidepressants. Furthermore, childhood trauma triggers epigenetic changes, which are associated with the pathophysiology of major depressive disorder (MDD). Treat- ment with atypical antipsychotics such as quetiapine, exerts therapeutic effect for MDD patients and induces ...

Effects of ketamine administration on mTOR and reticulum stress signaling pathw...

Recent studies show that activation of the mTOR signaling pathway is required for the rapid antide- pressant actions of glutamate N-methyl-D-aspartate (NMDA) receptor antagonists. A relationship be- tween mTOR kinase and the endoplasmic reticulum (ER) stress pathway, also known as the unfolded protein response (UPR) has been shown. We evaluate the effects of ketamine administration on the mTOR signaling pathway...