2 documents found, page 1 of 1
Targeting circulating labile heme as a defense strategy against malaria
Ramos, Susana; Jeney, Viktoria; Figueiredo, Ana; Paixão, Tiago; Sambo, Maria Rosário; Quinhentos, Vatúsia; Martins, Rui; Gouveia, ZéliaSevere presentations of malaria emerge as Plasmodium (P.) spp. parasites invade and lyse red blood cells (RBC), producing extracellular hemoglobin (HB), from which labile heme is released. Here, we tested whether scavenging of extracellular HB and/or labile heme, by haptoglobin (HP) and/or hemopexin (HPX), respectively, counter the pathogenesis of severe presentations of malaria. We found that circulating labil...
Transforming Growth Factor Beta 2 and Heme Oxygenase 1 Genes Are Risk Factors f...
Sambo, Maria Rosário; Trovoada, Maria Jesus; Benchimol, Carla; Quinhentos, Vatúsia; Gonçalves, Lígia; Velosa, Rute; Marques, Maria IsabelBACKGROUND: Cerebral malaria (CM) represents a severe outcome of the Plasmodium falciparum infection. Recent genetic studies have correlated human genes with severe malaria susceptibility, but there is little data on genetic variants that increase the risk of developing specific malaria clinical complications. Nevertheless, susceptibility to experimental CM in the mouse has been linked to host genes including T...