8 documents found, page 1 of 1
Bottom Up Ethics - Neuroenhancement in Education and Employment
Bard, I; Gaskell, G; Allansdottir, A; Cunha, R; Eduard, P; Hampel, J; Hildt, E; Hofmaier, C; Kronberger, N; Laursen, S; Meijknecht, A; Nordal, SNeuroenhancement involves the use of neurotechnologies to improve cognitive, affective or behavioural functioning, where these are not judged to be clinically impaired. Questions about enhancement have become one of the key topics of neuroethics over the past decade. The current study draws on in-depth public engagement activities in ten European countries giving a bottom-up perspective on the ethics and desira...
Body Fat Percentage Is a Major Determinant of Total Bilirubin Independently of ...
Belo, L; Nascimento, H; Kohlova, M; Bronze-da-Rocha, E; Fernandes, J; Costa, E; Catarino, C; Aires, L; Mansilha, HF; Rocha-Pereira, P; Quintanilha, AOBJECTIVES: Bilirubin has potential antioxidant and anti-inflammatory properties. The UGT1A1*28 polymorphism (TA repeats in the promoter region) is a major determinant of bilirubin levels and recent evidence suggests that raised adiposity may also be a contributing factor. We aimed to study the interaction between UGT1A1 polymorphism, hematological and anthropometric variables with total bilirubin levels in you...
Risk Factors for Mortality in Hemodialysis Patients: Two-Year Follow-Up Study
Sameiro Faria, M; Ribeiro, S; Costa, E; Mendonça, D; Teixeira, L; Rocha-Pereira, P; Fernandes, J; Nascimento, H; Kohlova, M; Reis, F; Amado, LBackground. End-stage renal disease (ESRD) patients under hemodialysis (HD) have high mortality rate. Inflammation, dyslipidemia, disturbances in erythropoiesis, iron metabolism, endothelial function, and nutritional status have been reported in these patients. Our aim was to identify any significant association of death with these disturbances, by performing a two-year follow-up study. Methods and Results. A l...
Adiponectin is an independent predictor of tissue plasminogen activator levels ...
Do Sameiro Faria, M; Ribeiro, S; Nascimento, H; Rocha-Pereira, P; Miranda, V; Mendonça, D; Quintanilha, A; Costa, E; Belo, L; Santos-Silva, AObjective. The aim of this study was to evaluate the association of tissue-type plasminogen activator (t-PA) levels with clinical data of patients under haemodialysis (HD) and with several variables potentially related to endothelial function and dysfunction. Material and methods. In a cross-sectional study involving 189 Portuguese HD patients, circulating levels of t-PA, lipids, oxidized low-density lipoprotei...
Oxidized low-density lipoprotein and lipoprotein(a) levels in chronic kidney di...
Ribeiro, S; Faria, MDS; Silva, G; Nascimento, H; Rocha-Pereira, P; Miranda, V; Vieira, E; Santos, R; Mendonça, D; Quintanilha, A; Costa, E; Belo, LChronic kidney disease (CKD) has been associated with an abnormal lipid profile. Our aim was to study the interplay between oxidized low-density lipoprotein (ox-LDL), adiponectin, and blood lipids and lipoproteins in Portuguese patients with CKD under hemodialysis (HD); the influence of the pentanucleotide repeat polymorphism in the apolipoprotein(a) (apo [a]) gene upon lipoprotein(a) (Lp[a]) levels in these pa...
Erythrocyte damage in mild and severe psoriasis
Rocha-Pereira, P; Santos-Silva, A; Rebelo, I; Figueiredo, A; Quintanilha, A; Teixeira, FBACKGROUND: Psoriasis is a common chronic and recurrent inflammatory skin disorder. Oxygen metabolites and proteases released by activated inflammatory cells may induce oxidative and proteolytic damage to plasma constituents and red blood cells (RBCs). RBCs have a limited biosynthesis capacity and poor repair mechanisms. OBJECTIVES: To study RBCs as a potential cumulative marker of oxidative and proteolytic str...
The inflammatory response in mild and in severe psoriasis
Rocha-Pereira, P; Santos-Silva, A; Rebelo, I; Figueiredo, A; Quintanilha, A; Teixeira, FBACKGROUND: Psoriasis is a chronic and recurrent inflammatory skin disease. The inflammatory response represents a fundamental ability of the organism to protect itself from infectious agents and from injury. OBJECTIVES: To evaluate the inflammatory response in mild and in severe psoriasis, to evaluate the endogenous systems counterbalancing the deleterious effects of the inflammation products, and to establish...
Abnormal NK cell lymphocytosis detected after splenectomy: association with rep...
Granjo, E; Lima, M; Fraga, M; Santos, F; Magalhães, C; Queirós, ML; Moreira, I; Rocha, S; Silva, AS; Rebelo, I; Quintanilha, A; Ribeiro, ML; Candeias, JAbnormal NK cell lymphocytosis detected after splenectomy: association with repeated infections, relapsing neutropenia, and persistent polyclonal B-cell proliferation. Granjo E, Lima M, Fraga M, Santos F, Magalhães C, Queirós ML, Moreira I, Rocha S, Silva AS, Rebelo I, Quintanilha A, Ribeiro ML, Candeias J, Orfão A. Department of Hematology, Hospital S. João, Porto, Portugal. npp46740@mail.telepac.pt Abstract W...