36 documents found, page 1 of 4
Resistência à terapêutica com eritropoietina humana recombinante em doentes hem...
Costa, Elísio; Lima, Margarida; Rocha, Susana; Rocha-Pereira, Petronila; Reis, Flávio; Castro, Elisabeth; Teixeira, Frederico; Miranda, VascoCom o objectivo de clarificar o mecanismo de resistência à terapêutica com eritropoietina humana recombinante (EPOhr) em doentes hemodializados, estudamos alterações a ela associada, com particular interesse na inflamação, activação leucocitária, ciclo do ferro, stress oxidativo e lesão eritrocitária. Foram estudados 63 doentes renais crónicos (DRC) em hemodiálise e terapêutica com EPOhr (32 respondedores e 31 ...
Body fat percentage is a major determinant of total bilirubin independently of ...
Belo, Luís; Nascimento, Henrique; Kohlova, Michaela; Bronze-da-Rocha, Elsa; Fernandes, João; Costa, Elísio; Catarino, Cristina; Aires, LuísaObjectives: Bilirubin has potential antioxidant and anti-inflammatory properties. The UGT1A1*28 polymorphism (TA repeats in the promoter region) is a major determinant of bilirubin levels and recent evidence suggests that raised adiposity may also be a contributing factor. We aimed to study the interaction between UGT1A1 polymorphism, hematological and anthropometric variables with total bilirubin levels in you...
Potential cardiovascular risk protection of bilirubin in end-stage renal diseas...
Faria, Maria do Sameiro; Kohlova, Michaela; Ribeiro, Sandra; Rocha-Pereira, Petronila; Teixeira, Laetitia; Nascimento, Henrique; Reis, FlávioWe evaluated the potential cardiovascular risk protection of bilirubin in hemodialysis (HD) patients. An enlarged set of studies were evaluated in 191 HD patients, including hematological study, lipid profile, iron metabolism, nutritional, inflammatory markers, and dialysis adequacy. The TA duplication screening in the UDP-glucuronosyltransferase 1 A1 (UGT1A1) promoter region was also performed. The UGT1A1 geno...
Risk factors for mortality in hemodialysis patients: two-year follow-up study
do Sameiro-Faria, Maria; Ribeiro, Sandra; Costa, Elísio; Mendonça, Denisa; Teixeira, Laetitia; Rocha-Pereira, Petronila; Fernandes, JoãoEnd-stage renal disease (ESRD) patients under hemodialysis (HD) have high mortality rate. Inflammation, dyslipidemia, disturbances in erythropoiesis, iron metabolism, endothelial function, and nutritional status have been reported in these patients. Our aim was to identify any significant association of death with these disturbances, by performing a two-year follow-up study. Methods and Results. A large set of ...
Ensaios Clínicos – Contextualização abreviada e alguns desafios
Quintanilha, Alexandre.
Main Determinants of PON1 Activity in Hemodialysis Patients
Ribeiro, Sandra; do Sameiro Faria, Maria; Mascarenhas-Melo, Filipa; Freitas, Isabel; Mendonca, Maria Isabel; Nascimento, HenriqueCardiovascular diseases are the major cause of morbidity and mortality in hemodialysis (HD) patients. These patients present reduced paraoxonase 1 (PON1) activity that depends on genetic and non-genetic factors; however, how these factors influence PON1 activity in HD patients is poorly clarified. Our aim was to evaluate the influence of two polymorphisms and non-genetic factors on PON1 activity in HD patients.
Cardiovascular risk factors in Portuguese obese children and adolescents: impac...
Nascimento, Henrique; Costa, Elísio; Rocha-Pereira, Petronila; Rego, Carla; Mansilha, Helena Ferreira; Quintanilha, Alexandre; Santos-Silva, AliceObjectives: Evaluate cardiovascular risk factors in Portuguese obese children and adolescents and the long-term effects of lifestyle modifications on such risk factors. Design: Transversal cohort study and longitudinal study. Setting: University Hospital S. João and Children's Hospital Maria Pia, Porto. Patients/Participants: 148 obese children and adolescents [81 females (54.7%); mean age of 11.0 years]and 33 ...
Hereditary spherocytosis -- prevalence of erythrocyte membrane protein deficiency.
Granjo, Elisa; Manata, Pedro; Torres, Noémia; Rodrigues, Lurdes; Ferreira, Fátima; Bauerle, Roswitha; Quintanilha, AlexandreThe authors studied the relative prevalence of erythroid cytoskeletal protein defects and their relationship with the clinical course of Hereditary Spherocytosis (HS) in 39 Portuguese patients of North of Portugal (25 families). This study showed that, in the North of Portugal, HS is primarily due to anquirin deficiency (72%), followed by band 3 (20%). These findings are similar to the published data in other C...
Erythrocyte membrane protein destabilization versus clinical outcome in 160 por...
Rocha, Susana; Costa, Elísio; Rocha-Pereira, Petronila; Ferreira, Fátima; Cleto, Esmeralda; Barbot, José; Quintanilha, Alexandre; Belo, LuisHereditary Spherocytosis (HS) is a haemolytic anaemia caused by erythrocyte protein membrane defects - spectrin, ankyrin, band 3 or protein 4.2 - that lead to membrane destabilization. This study aimed to evaluate the prevalence of protein deficiencies and the role of membrane proteins or membrane-linked proteins in membrane disturbance and in HS clinical outcome. A total of 215 Portuguese individuals were stud...
Neutrophil and monocyte activation in chronic kidney disease patients under hem...
Pereira, Rui; Costa, Elísio; Gonçalves, Marta; Miranda, Vasco; Faria, Maria do Sameiro; Quintanilha, Alexandre; Belo, Luís; Lima, MargaridaThe aim of the present work was to further clarify leukocyte activation due to hemodialysis (HD) procedures and to investigate its relationship with recombinant human erythropoietin resistance. Therefore, we studied the expression of CXCR1 and CD11b on neutrophils, as well as the monocyte expression of CD11b, HLA-DR, and CD14. We studied 34 chronic kidney disease (CKD) patients under HD and recombinant human er...