22 documents found, page 1 of 3
Central nervous system and analgesic profiles of Lippia genus
Siqueira-Lima,Pollyana S.; Passos,Fabiolla R.S.; Lucchese,Angélica M.; Menezes,Irwin R.A.; Coutinho,Henrique D.M.; Lima,Adley A.N.; Zengin,GokhanAbstract Many people use medicinal plants to relieve disorders related to the central nervous system, such as depression, epilepsy, anxiety and pain, even though the effectiveness of most of them has not yet been proven through scientific studies. Plants of the Lippia genus, Verbenaceae, are widely used in ethnobotany as a food, for seasoning and in antiseptic remedies. They are also marketed and used for the t...
Natural products assessed in animal models for orofacial pain – a systematic re...
Siqueira-Lima,Pollyana S.; Silva,Juliane C.; Quintans,Jullyana S.S.; Antoniolli,Angelo R.; Shanmugam,Saravanan; Barreto,Rosana S.S.; Santos,Márcio R.V.ABSTRACT Orofacial pain is related to tissues of the head, face, neck and all the intraoral structures; it is rather debilitating to the patient and also difficult to treat. There are relatively few studies dedicated to the use of natural products to alleviate orofacial pain in preclinical experiment models (performed in experimental animals which provide support for clinical trials). Main objectives of the pre...
Evaluation of the orofacial antinociceptive profile of the ethyl acetate fracti...
Falcão,Rosângela E.A.; Souza,Silvana A. de; Camara,Celso A.; Quintans,Jullyana S.S.; Santos,Priscila L.; Correia,Maria Tereza S.; Silva,Tania M.S.ABSTRACT Hyptis pectinata (L.) Poit., Lamiaceae, popularly known as "sambacaitá," is an aromatic shrub largely grown in the Brazilian northeastern. We investigated the antinociceptive effects of the ethyl acetate fraction obtained from the leaves of H. pectinata and of its main constituent rosmarinic acid, on formalin (2%)-, glutamate (25 µM)- and capsaicin (2.5 µg)-induced orofacial nociception in rodents. Mal...
Hyptis pectinata gel prevents alveolar bone resorption in experimental periodon...
Paixão,Mônica S.; Melo,Mônica S.; Damascena,Nicole P.; Araújo,Adriano A.S.; Soares,Andrea F.; Oliveira,Denise V.A.; Oliveira,Jeison S.Hyptis pectinata (L.) Poit., Lamiaceae, is an aromatic, abundant and broadly used plant species in Sergipe to treat oral and gastrointestinal pain and inflammation. The aim of the present study was to analyze the relation between periodontitis and changes in the corporal mass and alveolar bone structure after induction of experimental periodontal disease in rat treated or not treated with H. pectinata gel at 5%...
Phytochemical study and antinociceptive effect of the hexanic extract of leaves...
Quintans,Jullyana S.S.; Costa,Emmanoel V.; Tavares,Josean F.; Souza,Thais T.; Araújo,Silvan S.; Estevam,Charles S.; Barison,AnderssonCombretum duarteanum Cambess, Combretaceae, is a plant widely distributed in Northeastern Brazil and, in folk medicine, stems and leaves are used for pain treatment. We investigated the antinociceptive effects of the hexanic extract of leaves from C. duarteanum and of friedelin, its main compound, in formalin-, glutamate- and capsaicin- induced orofacial nociception models. In order to isolate friedelin from th...
Evaluation of wound healing activity of atranorin, a lichen secondary metabolit...
Barreto,Rosana S. S.; Albuquerque-Júnior,Ricardo L. C.; Pereira-Filho,Rose Nely; Quintans,Jullyana S. S.; Barreto,André S.; DeSantana,Josimari M.The aim of this study was to investigate the wound healing activity of atranorin cream (Patent requested) on excision wounds. Seventy-two male rats were anesthetized and an excisional wound was performed. Then the rats were randomly assigned into three groups: untreated control group; atranorin 1 (group treated with 1% AT ointment); and atranorin 5 (group treated with 5% AT ointment). Six animals of each group ...
Antinociceptive effects of an extract, fraction and an isolated compound of the...
Martins,Marina V.; Estevam,Charles dos S.; Santos,André L. L. M.; Dias,Antonio S.; Cupertino-da-Silva,Yolanda K.; Araújo-Júnior,João X.The antinociceptive activity of the Maytenus rigida Mart. (Celastraceae) ethanol extract and its ethyl acetate fraction as well as of (-)-4'-methylepigallocatechin (1), a previously isolated compound, was demonstrated in vivo. ED50 for 1 in the writhing test was 14.14 mg/kg. The acetic acid-induced writhing was inhibited by 98.4, 84.4, and 58.3%, respectively, when mice were treated with the ethanol extract, et...
Phytochemical screening, antinociceptive and anti-inflammatory effects of the e...
Andrade,Gilmara S.; Guimarães,Adriana G.; Santana,Marilia T.; Siqueira,Rosana S.; Passos,Luiz O.; Machado,Samísia M. F.; Ribeiro,Adauto de S.This report aimed to investigate the chemical composition and possible antinociceptive and anti-inflammatory effects of the essential oil from fresh leaves of Myrcia pubiflora DC., Myrtaceae (EOMP), through different experimental tests. The essential oil of M. pubiflora (EOMP) was obtained by hydrodistillation, analyzed by GC-MS, and tested at doses of 25, 50, and 100 mg/kg (i.p.) in three different tests of no...
Phytochemical screening, antinociceptive and anti-inflammatory activities of Ch...
Lima,Gabrielle M.; Quintans-Júnior,Lucindo J.; Thomazzi,Sara M.; Almeida,Emyle M. S. A.; Melo,Mônica S.; Serafini,Mairim R.; Cavalcanti,Sócrates C. H.Chrysopogon zizanioides (L.) Roberty, Poaceae, is a plant widely used in northeast Brazil in folk medicine for the treatment of various pathological conditions, including inflammatory pain. The present study evaluated the antinociceptive and anti-inflammatory effects of C. zizanioides essential oil (EO) in rodents. EO was further characterized by GC/MS. The major components of EO were identified as khusimol (19...
Essential oil composition and variability in Hyptis fruticosa
Franco,Clóvis R. P.; Alves,Péricles B.; Andrade,Daniela M.; Jesus,Hugo C. R. de; Silva,Eduardo J. S.; Santos,Esdras A. B.; Antoniolli,Ângelo R.The composition of six samples of essential oil (EO) extracted from leaves, flowers and seeds of several plants of Hyptis fruticosa Salzm. ex Benth., Lamiaceae, was investigated by GC/MS and GC/FID. 1,8-Cineole, spathulenol, α-pinene, β-pinene were the major constituents. Ten constituents that have not been previously described in the composition of the oil of H. fruticosa were identified. Hydrocarbons sesquite...