O lenvatinib é um fármaco usado em doentes com carcinoma hepatocelular (CHC) irressecável, devido à sua atividade antiangiogénica. Esta classe de fármacos mudou o paradigma do tratamento do CHC mas apresenta agora um desafio adicional devido aos efeitos secundários significativamente diferentes comparativamente à quimioterapia convencional. Apresentamos o caso de um homem de 58 anos com cirrose alcoólica e dism...
The healthcare context is undergoing a significant transformation, facing a series of complex and unprecedented challenges. This transformation is triggered by accessibility constraints to healthcare services, increased expectations from patients and sing financial burdens. Rather than being seen as unsolvable obstacles, these challenges can be perceived as powerful stimuli, encouraging the search for innovativ...
Introduction: Blood pressure (BP) measurement in the office has been the cornerstone in the diagnosis and follow-up of hypertensive patients. However, it constitutes an isolated assessment, which may not reflect day-to-day BP values. Home Blood Pressure Monitoring (HBPM) has been increansingly used, since it is associated with more reproducible BP values, aids in the diagnosis of white coat hypertension and mas...
Introduction: The correct measurement of blood pressure (BP) is essential for the diagnosis and approach of blood hypertension. The way to appropriately perform this measurement is described in the “Guidelines for the Management of Arterial Hypertension 2018” from the European Society of Cardiology. This work pretends to highlight the importance of performing three blood pressure measurements during the evaluat...
Paragangliomas are rare neuroendocrine tumors that arise from the extra-adrenal sympathetic and parasympathetic paraganglia. Most parasympathetic paragangliomas are nonfunctional, derived from non-chromaffin cells located in the neck and at the base of the skull. It is often necessary to exclude it in patients with early and severe arterial hypertension, or with therapeutic refractoriness. This case shows an ex...
Introduction: The Confusion Assessment Method for Intensive Care Unit (CAM-ICU) is of great potential value in the emergency department (ED). However, there is still uncertainty about its diagnostic accuracy and reliability, with studies warranting larger cohorts. In one of the largest and most heterogeneous cohorts considered to date, the aim was to vali[1]date and explore the applicability of the CAM-ICU (Eur...
Hereditary hemorrhagic telangiectasia is a rare disorder affecting the vasculature of several organs. Stroke and brain abscess are rare complications associated with paradoxical embolism due to pulmonary arteriovenous malformations. We describe a case of a 45-year-old woman that presented those two life-threatening neurologic complications within a year; this occurred because the pulmonary arteriovenous malform...
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Introduction: Transmission of COVID-19 through close contact and droplets is well established, but the influence of aerosol and surface contamination remains to be determined. Literature is scarce and inconsistent about the viable virus particles free-distance from infected patients, as well as about different swabbing methods for surface contamination evaluation. The aim of this study was to evaluate the most ...