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Endolysosomal degradation of Tau and its role in glucocorticoid-driven hippocam...

Vaz-Silva, João; Gomes, Patrícia; Jin, Qi; Zhu, Mei; Zhuravleva, Viktoriya; Quintremil, Sebastian; Meira, Torcato Duarte Novo; Silva, Joana

Emerging studies implicate Tau as an essential mediator of neuronal atrophy and cognitive impairment in Alzheimer's disease (AD), yet the factors that precipitate Tau dysfunction in AD are poorly understood. Chronic environmental stress and elevated glucocorticoids (GC), the major stress hormones, are associated with increased risk of AD and have been shown to trigger intracellular Tau accumulation and downstre...

Date: 2018   |   Origin: RepositóriUM - Universidade do Minho
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