10 documents found, page 1 of 1
Allogenic synovia-derived mesenchymal stem cells for treatment of equine tendin...
Reis, Inês Leal; Lopes, Bruna; Sousa, Patrícia; Sousa, Ana Catarina; Branquinho, Mariana; Caseiro, Ana Rita; Pedrosa, Sílvia Santos; Rêma, AlexandraTendon and ligament injuries are frequent in sport horses and humans, and such injuries represent a significant therapeutic challenge. Tissue regeneration and function recovery are the paramount goals of tendon and ligament lesion management. Nowadays, several regenerative treatments are being developed, based on the use of stem cell and stem cell-based therapies. In the present study, the preparation of equine...
Rat olfactory mucosa mesenchymal stem/stromal cells (om-mscs): a characterizati...
Alvites, Rui D.; Branquinho, Mariana V.; Caseiro, Ana R.; Amorim, Irina; Pedrosa, Sílvia Santos; Rêma, Alexandra; Faria, Fátima; Porto, BeatrizStem/stromal cell-based therapies are a branch of regenerative medicine and stand as an attractive option to promote the repair of damaged or dysfunctional tissues and organs. Olfactory mucosa mesenchymal stem/stromal cells have been regarded as a promising tool in regenerative therapies because of their several favorable properties such as multipotency, high proliferation rate, helpful location, and few associ...
Histochemical and immunohistochemical evaluation of angiogenesis in rabbits (Or...
Pazzini, Josiane M. [UNESP]; Serafim, Eduardo L. [UNESP]; Gärtner, Fátima; Amorim, Irina; Faria, Fátima; Rêma, Alexandra; Moraes, Paola C. [UNESP]Made available in DSpace on 2018-12-11T17:18:39Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-12-01. Added 1 bitstream(s) on 2019-10-09T18:31:33Z : No. of bitstreams: 1 S0100-736X2017001201519.pdf: 3105779 bytes, checksum: e7e2b1d54005cd3be7ef11220dbb4333 (MD5); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Histochemical staining consists of a set of specific chemical reactions o...
Long term performance evaluation of small-diameter vascular grafts based on pol...
Alexandre, Nuno; Amorim, Irina; Caseiro, Ana Rita; Pereira, Tiago; Alvites, Rui; Rêma, Alexandra; Gonçalves, Ana; Costa, Elisio; Santos-Silva, AliceThe functional and structural performance of a 5 cm synthetic small diameter vascular graft (SDVG) produced by the copolymerization of polyvinyl alcohol hydrogel with low molecular weight dextran (PVA/Dx graft) associated to mesenchymal stem cells (MSCs)-based therapies and anticoagulant treatment with heparin, clopidogrel and warfarin was tested using the ovine model during the healing period of 24 weeks. The ...
HFE variants and the expression of iron-related proteins in breast cancer-assoc...
Marques, Oriana; Rosa, Ana; Leite, Luciana; Faustino, Paula; Rêma, Alexandra; Martins da silva, Berta; Porto, Graça; Lopes, CarlosThe association of HFE (High Iron FE) major variants with breast cancer risk and behavior has been a matter of discussion for a long time. However, their impact on the expression of iron-related proteins in the breast cancer tissue has never been addressed. In the present study, hepcidin, ferroportin 1, transferrin receptor 1 (TfR1), and ferritin expressions, as well as tissue iron deposition were evaluated in ...
Development of an embryotoxicity test for Enchytraeus crypticus: the effect of Cd
Gonçalves, Micael F. M.; Bicho, Rita C.; Rêma, Alexandra; Soares, Amadeu M. V. M.; Faustino, Augusto M. R.; Amorim, Mónica J. B.The existing standard enchytraeid reproduction test (ERT) concerns the assessment of effects on survival and reproduction. In the present study we optimized and propose an embryotoxicity test using Enchytraeus crypticus. Cadmium (Cd) was used as a test substance. Endpoints evaluated were embryo development, number of embryonic structures, Calcium (Ca) channels quantification and hatching success with macroscopi...
Endocrine disruption effects of p,p'-DDE on juvenile zebrafish
Monteiro, Marta Sofia; Pavlaki, Maria; Faustino, Augusto; Rêma, Alexandra; Franchi, Mariana; Gediel, Letícia; Loureiro, Susana; Domingues, InêsThe persistent organic pollutant p,p′-DDE, the major metabolite of the insecticide DDT, has displayed evidence of endocrine disruption through the inhibition of androgen binding to androgen receptors in different species. Although p,p′-DDE was continuously detected in wild fish with abnormal gonad development such as intersex, little is known about its mode of action during gonad development in fish. To elucida...
An immunohistochemical study on the expression of sex steroid receptors, Ki-67 ...
Saraiva, Ana Laura da Silva Santos; Gärtner, Fátima; Cunha, Marta R. Fortuna da; Rêma, Alexandra; Faria, Fátima; Lourenço, Lígia M.
Thyroid disruption in the lizard Podarcis bocagei exposed to a mixture of herbi...
Bicho, Rita C.; Amaral, Maria José; Faustino, Augusto M. R.; Power, Deborah M.; Rêma, Alexandra; Carretero, Miguel A.; Soares, Amadeu M. V. M.Pesticide exposure has been related with thyroid disrupting effects in different vertebrate species. However, very little is known about the effects of these compounds in reptiles. In the Mediterranean area, lacertid lizards are the most abundant vertebrate group in agroecosystems, and have been identified as potential model species for reptile ecotoxicology. The aim of this study was to understand if the herbi...
Thyroid disruption in the lizard Podarcis bocagei exposed to a mixture of herbi...
Bicho, Rita C.; Amaral, Maria José; Faustino, Augusto M. R.; Power, Deborah; Rêma, Alexandra; Carretero, Miguel A.; Soares, Amadeu M. V. M.Pesticide exposure has been related with thyroid disrupting effects in different vertebrate species. However, very little is known about the effects of these compounds in reptiles. In the Mediterranean area, lacertid lizards are the most abundant vertebrate group in agroecosystems, and have been identified as potential model species for reptile ecotoxicology. The aim of this study was to understand if the herbi...