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Mapping mania symptoms based on focal brain damage

Cotovio, Gonçalo; Talmasov, Daniel; Bernardo Barahona-Corrêa, J.; Hsu, Joey; Senova, Suhan; Ribeiro, Ricardo; Soussand, Louis; Velosa, Ana

BACKGROUND. Although mania is characteristic of bipolar disorder, it can also occur following focal brain damage. Such cases may provide unique insight into brain regions responsible for mania symptoms and identify therapeutic targets. METHODS. Lesion locations associated with mania were identified using a systematic literature search (n = 41) and mapped onto a common brain atlas. The network of brain regions f...


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