20 documents found, page 1 of 2
Economic impact of localized cutaneous leishmaniasis on adult patients of a ref...
Galvão,Endi Lanza; Assis,Talia Santana Machado de; Pedras,Mariana Junqueira; Cota,Gláucia Fernandes; Simões,Taynãna César; Rabello,AnaCutaneous leishmaniasis (CL) is a disease associated with low-income populations. Thus, in assessing the burden of this disease, it is important to include its economic impact on individuals. We aimed to evaluate CL economic impact on patients treated at a referral service in the State of Minas Gerais, Brazil. This is a cross-sectional study based on the analysis of interviews and medical records from which we ...
Mucosal leishmaniasis: the experience of a Brazilian referral center
Pedras,Mariana Junqueira; Carvalho,Janaína de Pina; Silva,Rosiana Estéfane da; Ramalho,Dario Brock; Senna,Maria Camilo Ribeiro deAbstract INTRODUCTION Pentavalent antimonials (Sbv) are the most commonly used drugs for the treatment of mucosal leishmaniasis (ML), despite their high toxicity and only moderate efficacy. The aim of this study was to report therapeutic responses with different available options for ML. METHODS This study was based on a review of clinical records of 35 patients (24 men and 11 women) treated between 2009 and 20...
Budgetary impact of diagnostic tests for visceral leishmaniasis in Brazil
Assis,Tália Santana Machado de; Azeredo-da-Silva,André Luís Ferreira de; Oliveira,Diana; Cota,Gláucia; Werneck,Guilherme Loureiro; Rabello,AnaAbstract: The aim of the present study was to estimate the financial costs of the incorporation and/or replacement of diagnostic tests for human visceral leishmaniasis (VL) in Brazil. The analysis was conducted from the perspective of the Brazilian Unified National Health System (SUS) over a period of three years. Six diagnostic tests were evaluated: the indirect immunofluorescence antibody test (IFAT), the IT ...
The direct costs of treating human visceral leishmaniasis in Brazil
Assis,Tália Santana Machado de; Rosa,Dian Carlos Pinheiro; Teixeira,Eliane de Morais; Cota,Gláucia; Azeredo-da-Silva,André Luís FerreiraAbstract INTRODUCTION: The drugs available for visceral leishmaniasis (VL) treatment in Brazil have specific characteristics in terms of operability, effectiveness, toxicity, and cost. The aim of this study was to estimate the direct costs of therapies recommended by the Ministry of Health (MH) for VL treatment in Brazil. METHODS: The analytical perspective used was that adopted by the Brazilian Public Health S...
Study of implementation and direct cost estimates for diagnostic tests for huma...
Assis,Tália Santana Machado de; Guimarães,Paloma Nogueira; Oliveira,Edward; Peruhype-Magalhães,Vanessa; Gomes,Luciana Inácia; Rabello,AnaAbstract This work reports the process and costs of comprehensively implementing two tests to decentralize the diagnosis of visceral leishmaniasis (VL) in an endemic city in Brazil: a rapid test (IT LEISH) and a direct agglutination test (DAT-LPC). The implementation began by training health professionals to perform the tests. Estimation of the training costs considered the proportional remuneration of all prof...
Poor response to azithromycin in cutaneous leishmaniasis leading to a premature...
Toledo Junior,Antonio; Daher,André Bastos; Amaral,Thaís Alves; Carvalho,Sílvio Fernando Guimarães; Romero,Gustavo Adolfo Sierra; Rabello,AnaIntroduction Parenteral antimony-based compounds are still the standard of care for cutaneous leishmaniasis (CL) treatment in many countries, despite their high toxicity. Previous studies showed that oral azithromycin could be an option for CL treatment. The aim of this study was to evaluate efficacy and safety of oral azithromycin (AZ) for CL treatment compared with injectable meglumine antimoniate (MA). Metho...
Diagnosing schistosomiasis: where are we?
Gomes,Luciana Inácia; Enk,Martin Johannes; Rabello,AnaIn light of the World Health Organization's initiative to extend schistosomiasis morbidity and mortality control programs by including a disease elimination strategy in low endemic settings, this paper reviews diagnostic tools described during the last decades and provide an overview of ongoing efforts in making an efficient diagnostic tool available worldwide. A literature search on PubMed using the search cri...
Factors of poor prognosis of visceral leishmaniasis among children under 12 yea...
Braga,Alexandre Sérgio da Costa; Toledo Junior,Antonio Carlos de Castro; Rabello,AnaINTRODUTION: A major concern with the visceral leishmaniasis (VL) is its high lethality rate, even with proper treatment. Low age, prior malnutrition, disease duration prior to diagnosis, severe anemia, fever for more than 60 days, diarrhea and jaundice are known poor prognostic factors. The goals of this study are to describe the clinical and laboratory characteristics of VL among children under 12 years of ag...
Chemical constituents and leishmanicidal activity from leaves of Kielmeyera var...
Cota,Betania B.; Siqueira,Ezequias P.; Oliveira,Djalma M. de; Alves,Tânia M. A.; Sobral,Marcos E. G.; Rabello,Ana; Zani,Carlos L.Many phenolic compounds such as xanthones, quinones and coumarins have been isolated from Kielmeyera species; however the presence of flavonoids have been showed in other genera in the Calophylleae tribe as Caraipa, Mesua and Calophyllum. Six known glycosidic flavonoids: quercetin 3-β-O-galactopyranoside (1), quercetin 3-β-O-glucopyranoside (2), quercetin 3-O-α-rhamnoside (3), luteolin 6-C-β-glucopyranoside (4)...
Slow clinical improvement after treatment initiation in Leishmania/HIV coinfect...
Souza,Guenael Freire de; Biscione,Fernando; Greco,Dirceu Bartolomeu; Rabello,AnaINTRODUCTION: In Brazil there is a large area of overlap of visceral leishmaniasis (VL) and HIV infection, which favored a increased incidence of coinfection Leishmania/HIV. METHODS: This study evaluated 65 consecutive patients with VL and their clinical response to treatment in two health care settings in Belo Horizonte, Brazil. RESULTS: At baseline, the clinical picture was similar between both groups, althou...